| 血管内皮生长因子受体在膀胱癌中的表达及临床意义 |
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| 引用本文： | 李志,刘禄成,郭航. 血管内皮生长因子受体在膀胱癌中的表达及临床意义[J]. 中国免疫学杂志, 2005, 21(3): 230-232 |
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| 作者姓名： | 李志 刘禄成 郭航 |
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| 作者单位： | 吉林大学第二医院泌尿外科,长春130041 |
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| 摘 要： | 目的：探讨血管内皮生长因子受体在膀胱癌中的表达及与临床病理因素的相关性。方法：免疫组化法采用链霉菌抗生物素一过氧化物酶连接法(SP法)对50例膀胱癌标本，20例正常膀胱组织标本中血管内皮生长因子受体的表达进行检测。结果：血管内皮生长因子受体在大多数膀胱癌组织中表达(74％)，而且其表达水平与病理分期及组织分级呈正相关。在正常膀胱组织中无1例表达(0％)。结论：膀胱癌组织中血管内皮生长因子受体阳性表达，提示其在膀胱癌的血管生成中起着重要作用。
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| 关 键 词： | 膀胱癌 受体 血管内皮生长因子 免疫组织化学 |
| 文章编号： | 1000-484X(2005)03-0230-03 |
Expression of vascular endothelial growth factor receptor in bladder carcinoma |
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| LI Zhi,LIU Lu-cheng,GUO Hang. Expression of vascular endothelial growth factor receptor in bladder carcinoma[J]. Chinese Journal of Immunology, 2005, 21(3): 230-232 |
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| Authors: | LI Zhi LIU Lu-cheng GUO Hang |
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| Affiliation: | LI Zhi,LIU Lu-Cheng,GUO Hang.Department of Urology,The Second Hospital of Jilin University,Changchun 130041,China |
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| Abstract: | Objective:To study vascular endothelial growth factor receptor (VEGFR) in bladder carcinoma and its relationship with clinical pathology.Methods:VEGFR of bladder carcinoma samples (50 cases) and normal bladder tissues (20 cases) was detected with immunohistochemistry which was streptomyces-antibiotin-peroxidase-linkage-Technique (Technique SP).Results:VEGFR was positive in most of bladder carcinoma cases.Percentage was 74%.Expression level had positive relationship with pathologicl level and tissue grade.Conclusion:VEGFR was positive in bladder carcinoma.It indicated that VEGFR had important function in angiogenesis of bladder carcinoma. [ |
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| Keywords: | Bladder carcinoma Receptor Vascular endothelial growth factor Immunohistochemistry |
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