不同剂量氯吡格雷对不稳定型心绞痛患者血小板功能及血流变的影响

目的 探讨不同维持剂量氯吡格雷对不稳定型心绞痛(UAP)患者血小板功能及血流变的影响.方法 选取100 例UAP患者,随机分为对照组及实验组,每组各50例.在冠心病常规治疗基础上,对照组每日给予氯吡格雷75mg/d,实验组给予氯吡格雷150mg/d.分别于服药前及服药后两周采集两组患者静脉血,采用比浊法测定血小板聚集率(MPAR),同时监测血流变指标.结果 服药前两组MPAR及血流变指标比较,差异无统计学意义(P＞0.05);服药两周后两组上述指标较服药前均明显降低,与服药前比较及两组间比较,差异均统计学意义(P＜0.05).结论 150mg/d维持量氯吡格雷可显著降低UAP患者血小板聚集功能,改善其血液流变学指标,有效缓解症状,减少不良事件的发生.

Effects of Different Doses of Clopidogrel on Platelet Function and Hemorheology in Patients with Unstable Angina Pectoris

Objective To investigate the effects of different doses of clopidogrel on platelet function and hemorheology in patients with unstable angina pectoris.Methods One hundroud patients with unstable angina pectoris were randomly divided into groups:the control group(50 cases,treated with 75mg clopidogrel daily);the test group(50 cases,treated with 150mg clopidogrel daily).MPAR and hemorheology were measured on the baseline and after treatment.Results After treatment,the MPAR and hemorheology significantly decreased in both two groups,and there were significant differences between the two groups on these items.Conclusion Compared to the dose of 75mg clopidogrel,a higher dose of clopidogrel can produce much more faster,greater latelet inhibition,improve the hemorheological condition of patients.