诱导痰液分析对咳嗽变异性哮喘患者的诊断价值研究

目的 探讨诱导痰液分析在咳嗽变异性哮喘(CVA)中的临床诊断价值.方法 选取我院2009年9月-2011年8月79例变异性哮喘患者.采用超声雾化吸入3%～5%的高渗盐水进行诱导排痰,对其痰液进行嗜酸性粒细胞(EOS)百分率、肥大细胞(MC)百分率、中性粒细胞(N)及嗜酸性粒细胞阳离子蛋白(ECP)等检测,同时对1s用力呼气容积(FEVl)及ls用力呼气占预计值的百分比(FEVl占预计值%)进行测定.结果 其中有35例被临床诊断为CVA,患者的痰液中MC、EC百分率、ECP浓度、FEVl及FEVl占预计值%与对照组比较,差异均有统计学意义(P＜0.05),而与典型支气管哮喘组的比较差异无统计学意义(P＞0.05).在进行抗炎治疗之后患者的咳嗽症状很快得到缓解,对痰液中MC、EC百分率、ECP浓度、FEVl及FEVl占预计值%做出复测,结果与治疗前比较,差异有统计学意义.结论 通过痰液分析,从实验室角度阐明CVA存在气道炎症,为其诊断和治疗提供了一项可靠的评价指标.

The Diagnosis of Cough Variant Asthma-induced Sputum

Objective To investigate the induced sputum analysis in cough variant asthma(CVA)in the clinical application.Methods Our hospital from September 2009 to August 2011,79 cases of variant asthma patients,the use of ultrasonic inhalation of 3% to 5% hypertonic saline induced sputum,sputum eosinophils of its cells(EOS)percentage of mast cells(MC)percentage of neutrophils(N)and eosinophil cationic protein(ECP)and other testing,while forced expiratory volume in ls(FEVl)and forced expiratory-ls percentage of predicted value pereentage(FEV1% predicted)were measured.Results Of which 35 cases were clinically diagnosed as suffering from CVA,the patient′s sputum MC,EC percentage,ECP concentrations,FEVl and FEV1% predicted compared with the control group,were significant differences(P<0.05),with a typical comparison of bronchial asthma group there was no significant difference(P>0.05).During the anti-inflammatory treatment in patients with cough soon after to ease of sputum MC,EC percentage,ECP concentrations,FEVl and FEV1% predicted to retesl the results compared with before treatment,the difference was significant.Conclusion Sputum analysis,CVA from the laboratory point of view there is dear airway inflammation,its diagnosis and treatment are provided a keliable evaluation.