声脉冲辐射力成像技术评价慢性乙型肝炎肝纤维化程度的研究

目的分析声脉冲辐射力成像技术在肝纤维化诊断中的应用价值。方法利用声辐射力脉冲成像技术对52例慢性乙型肝炎患者和31例健康人肝脏右叶进行检查,测得感兴趣区肝脏组织声触诊组织量化(VTQ)值,并与肝活检组织病理学检查结果相比较。结果慢性乙型肝炎患者肝脏VTQ值显著高于健康人(P=0.012),VTQ值与肝纤维化程度呈正相关(Spearman r=0.737,P<0.01);将肝组织病理学检查结果≤G2S2合并为轻度肝纤维化组,≥G3S3合并为中/重度肝纤维化组,结果 VTQ诊断中/重度肝纤维化的VTQ值的cut-off值为1.6m/s,其诊断中/重度肝纤维化的敏感度为93.8%,特异度为73.7%,准确性为85.1%。结论声脉冲辐射力成像技术在慢性乙型肝炎患者对评估肝纤维化程度有重要的价值。

Acoustic radiation force impulse in evaluation of liver fibrosis in patients with chronic hepatitis B

Objective To analyse the application value of acoustic radiation force impulse in diagnozing liver fibrosis.Method The right lobes of the liver in 52 patients with chronic hepatitis B and 31 healthy subjects were checked by acoustic radiation force impulse imaging technology in order to measure quantitative value of liver tissue elasticity in regions of interest.Result The virtual touch quantification(VTQ)values in patients with chronic hepatitis B were higher than that in healthy control(P=0.012);The VTQ value was positively correlated to the degrees of liver fibrosis(Spearman r=0.737,P<0.01);The liver biopsy results of ≥G3S3 were considered as middle/high-staging liver fibrosis;The VTQ value of 1.6m/s was used as cut-off value and its sensitivity was 93.8%,the specificity was 73.7%and the accuracy was 85.1% to diagnose middle/high-staging liver fibrosis.Conclusion Acoustic radiation force impulse imaging technology might reflect quantitative information of the liver tissue elasticity,which can be used to assess the degree of liver fibrosis.