| Review of the Mechanisms of Action of the Statins and Their Pleiotropic Effects in the Treatment of Hypercholesterolemia and Atherosclerosis |
| |
| 作者姓名： | MODUTLWADawsonNkaelang LiZhi-you YOUQi-dong |
| |
| 作者单位： | DepartmentofMedicinalChemistry,ChinaPharmaceuticalUniversity,Nanjing210009,P.R.China |
| |
| 摘 要： | Statins are lipid-towering agents widely used in the treatment of hyperchotesterotemia and atherosclerosis. They act by inhibiting of 3-hydroxy-3-methytgtutaryl-coenzyme A (HMG-CoA) reductase, an enzyme responsible for the conversion of HMG-CoA to mevatonate in cholesterol biosynthesis. Due to their ability to reduce low-density tipoproteins (LDL) Levels more than other cholesterol-lowering drugs, they have become the drugs most often prescribed in the treatment of atheroscterosis.
|
| 关 键 词： | 高胆固醇血症 动脉粥样硬化症 药物疗法 药理作用 HMG-CoA 胆固醇 |
Review of the Mechanisms of Action of the Statins and Their PleiotropicEffects in the Treatment of Hypercholesterolemia and Atherosclerosis |
| |
| MODUTLWADawsonNkaelang LiZhi-you YOUQi-dong.Review of the Mechanisms of Action of the Statins and Their Pleiotropic Effects in the Treatment of Hypercholesterolemia and Atherosclerosis[J].Journal of Nanjing Medical University,2004,18(1):48-51. |
| |
| Authors: | MODUTLWA Dawson Nkaelang LI Zhi-you YOU Qi-dong |
| |
| Abstract: | Statins are lipid-lowering agents widely used in the treatment of hypercholesterolemia and atherosclerosis. They act by inhibiting of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, an enzyme responsible for the conversion of HMG-CoA to mevalonate in cholesterol biosynthesis. Due to their ability to reduce low-density lipoproteins (LDL) levels more than other cholesterol-lowering drugs, they have become the drugs most often prescribed in the treatment of atherosclerosis. |
| |
| Keywords: | hypercholesterolemia atherosclerosis HMG-CoA reductase inhibitors mevalonate |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
