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A randomized study comparing Crinone 8% and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles |
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| Authors: | Anthony M. Propst M.D. Joseph A. Hill M.D. Elizabeth S. Ginsburg M.D. Shelley Hurwitz Ph.D. Joseph Politch Ph.D. Elena H. Yanushpolsky M.D. |
| Affiliation: | a Center for Reproductive Medicine, Division of Reproductive Medicine, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA |
| Abstract: | Objective: To compare the efficacy of Crinone 8% intravaginal progesterone gel vs. IM progesterone for luteal phase and early pregnancy support after IVF-ET. Design: Randomized, open-label study. Setting: Academic medical center. Patient(s): Two hundred and one women undergoing IVF-ET. Intervention(s): Women were randomized to supplementation with Crinone 8% (90 mg once daily) or IM progesterone (50 mg once daily) beginning the day after oocyte retrieval. Main Outcome Measure(s): Pregnancy, embryo implantation, and live birth rates. Result(s): The women randomized to luteal phase supplementation with IM progesterone had significantly higher clinical pregnancy (48.5% vs. 30.4%; odds ratio [OR], 2.16; 95% confidence interval [CI], 1.21, 3.87), embryo implantation (24.1% vs. 17.5%; OR, 1.89; 95% CI, 1.08, 3.30), and live birth rates (39.4% vs. 24.5%; OR, 2.00; 95% CI, 1.10, 3.70) than women randomized to Crinone 8%. Conclusion(s): In women undergoing IVF-ET, once-a-day progesterone supplementation with Crinone 8%, beginning the day after oocyte retrieval, resulted in significantly lower embryo implantation, clinical pregnancy, and live birth rates compared with women supplemented with IM progesterone. |
| Keywords: | Progesterone Crinone luteal phase supplementation implantation in vitro fertilization embryo transfer cycles |
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