Reference range of thyroid function (FT3, FT4 and TSH) among Indian adults |
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| Authors: | Raman Kumar Marwaha Nikhil Tandon Mohd Ashraf Ganie Neena Mehan Aparna Sastry M.K. Garg Kuntal Bhadra Satveer Singh |
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| Affiliation: | 1. Department of Endocrinology and Thyroid Research Centre, Institute of Nuclear Medicine and Allied Sciences, Timarpur, India;2. Army Referral and Research Hospital, New Delhi, India;3. Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi 110054, India;4. B. R. Sur Homeopathy Medical College, New Delhi, India;5. Department of Endocrinology Sher-i-Kashmir Institute of Medical Sciences Srinagar, J & K, India;1. Medical Oncology and Pharmacology, CERIA, Cochin-Port Royal Hospital, AP-HP, Paris, 75014, France;1. Multidisciplinary Research Unit, Government Medical College, Haldwani, Nainital, Uttarakhand, India;2. Department of Biochemistry, Government Medical College, Haldwani, Nainital, Uttarakhand, India;3. Department of ENT, Government Medical College, Haldwani, Nainital, Uttarakhand, India;4. Department of Pathology, Government Medical College, Haldwani, Nainital, Uttarakhand, India;1. Department of Internal Medicine, Instituto Nacional de Ciencias Médicas, Y Nutrición “Salvador Zubirán”, Vasco de Quiroga #15, Col. Sección XVI, Tlalpan, México, DF CP: 14000, Mexico;2. Department of Nuclear Medicine, Instituto Nacional de Ciencias Médicas, Y Nutrición “Salvador Zubirán”, Vasco de Quiroga #15, Col. Sección XVI, Tlalpan, México, DF CP: 14000, Mexico;1. Servicio de Medicina Intensiva, Hospital Universitario del Tajo, Aranjuez, Madrid, Spain;2. Servicio de Medicina Intensiva, Hospital Universitario La Paz, Madrid, Spain;3. Servicio de Medicina Intensiva, Hospital General Universitario de Alicante, Alicante, Spain;4. Servicio de Medicina Intensiva, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain |
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| Abstract: | ObjectivesTo generate thyroid hormone reference norms using electro-chemiluminescence technique.Design and methodsCross sectional study on apparently normal 4349 Delhi adults (18–86 years). Predetermined exclusion criteria (goiter, hypoechogenicity or nodularity on ultrasound, elevated anti-thyroid peroxidase antibody, hypo or hyperthyroidism and family history of thyroid dysfunction) excluded 2433 subjects leaving 1916 (916 males and 1000 females) as the reference population.ResultsMean age and BMI of the reference population were 41.2 ± 18.1 years and 24.5 ± 4.4 kg/m2 respectively. Median urinary iodine excretion was 233.6 μg/L (79–458;3rd–97th centile). The population was categorized into various age groups (18–30, 31–40, 41–50, 51–60, 61–70 and ≥ 70 years). Overall FT3 and FT4 values in the reference population irrespective of age, ranged from 2.4–8.8 (mean 4.6 ± 0.9) pmol/L and 10.1–24.8 (mean 15.40 ± 2.0) pmol/L, respectively. Mean TSH value in the reference population was 2.2 ± 0.9 mIU/L which was significantly lower than that of total population (3.8 ± 6.1; p < 0.001).ConclusionFT3 values were observed to be significantly higher in men than women (p = 0.001). The centiles (3rd, 5th, 10th, 25th, 50th, 75th, 90th, 95th and 97th) of FT3, FT4 and TSH were derived for reference purposes in Indian adults. This community based study in Indian adults has established mean reference intervals for FT3, FT4 and TSH for different age groups for both sexes separately using strict exclusion criteria. These can be used as reference norms for Indian adults. |
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