高剂量卡格列净对2型糖尿病安全性的Meta分析

目的 系统评价高剂量卡格列净对2型糖尿病患者的安全性.方法 检索PubMed、Medline、Cochrane Library、Embase、中国知网、万方数据、维普网、中国生物医学文献数据库,检索时间为建库至2019年9月23日,收集卡格列净低剂量(100 mg/d)及高剂量(300 mg/d)用于治疗2型糖尿病的随...

Safety of High-dose Canagliflozin for Type 2 Diabetes Mellitus:A Meta Analysis

Objective To evaluate the safety of high-dose canagliflozin(CANA)in the treatment of type 2 diabetes mellitus(T2DM).Methods PubMed,Medline,Cochrane Library,Embase,CNKI,Wanfang Database,VIP and CBM were searched for randomized controlled trials(RCTs)published from the inception of the database to September 2019.Data on randomized controlled trials related to canagliflozin at a low dose of 100 mg/d and at a high dose of 300 mg/d used for treating type 2 diabetes mellitus was collected and analyzed using the RevMan5.3 software.Results A total of 14 RCTs and 6,233 cases of patients were included.Meta analysis results showed that high doses of calpagliflozin were more likely to cause male genital fungal infections,and the difference was statistically significant[RR=1.38,95%CI(1.06,1.79),P=0.02].The risk was also higher for volume depletionrelated AEs and the difference was statistically significant[RR=1.44,95%CI(1.05,1.98),P=0.03].LDL-C levels increased more significantly,and the difference was statistically significant[MD=0.05,95%CI(0.00,0.10),P=0.04].The occurrence of ther difference was basically similar to that of low dose.Conclusion High-dose canaglif102in can in rease the risk of male genital fungal infections,volume depletion-related AEs.and elevated the LDL-C levels There is no significant difference in the occurrence of other adverse reactions.However,this conclusion needs to be verified by long-term RCTs.