Methionine sulfoxide reductase A rs10903323 G/A polymorphism is associated with increased risk of coronary artery disease in a Chinese population |
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Authors: | Haiyong Gu Weiqiang Chen Jun Yin Suocheng Chen Jian Zhang Jie Gong |
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Institution: | 1. Department of Cardiothoracic Surgery, Affiliated People''s Hospital of Jiangsu University, Zhenjiang 212002, China;2. Department of Cardiovascular Medicine, Cardiovascular Clinical College of Tianjin Medical University & TEDA International Cardiovascular Hospital, Tianjin 300457, China;3. Department of Cardiology, Wuxi People''s Hospital Affiliated to Nanjing Medical University, Wuxi 214002, China;1. Human Genetics group, Genome Institute of Singapore, Singapore;2. Department of Pediatrics, National University of Singapore, Singapore;3. Unit of Epidemiology, Hebrew University School of Public Health, Jerusalem, Israel;1. Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland;2. Department of Genetics and Pathomorphology, Pomeranian Medical University, Szczecin, Poland;3. Department of Cardiology, Marie Curie Hospital, Szczecin, Poland |
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Abstract: | ObjectiveCoronary artery disease (CAD) is a complex disease resulting from a combination of environmental and genetic factors. We hypothesized that polymorphisms in methionine sulfoxide reductase A (MSRA: rs10903323 G/A) and vascular endothelial growth factor A (VEGFA: rs699947 C/A, rs2010963 G/C, and rs3025039 C/T) contribute to CAD susceptibility.Designs and methodsWe examined the association between the four polymorphisms and the risk of CAD in a Chinese population of 435 CAD patients and 480 controls. Genotyping was performed using matrix-assisted laser desorption ionization/time-of-flight mass spectrometry (MALDI/TOF-MS).ResultsWhen the MSRA rs10903323 GG homozygous genotype was used as the reference group, the GA and GA/AA genotypes were associated with a significantly increased risk of CAD (GA vs GG: adjusted OR = 1.36, 95% CI = 1.02–1.82, p = 0.038; GA/AA vs GG: adjusted OR = 1.33, 95% CI = 1.01–1.76, p = 0.042). The AA homozygous genotype was not associated with a risk of CAD. In the recessive model, when the MSRA rs10903323 GG/GA genotypes were used as the reference group, the AA homozygous genotype was not associated with a risk of CAD. Logistic regression analyses revealed that the VEGFA rs699947 C/A, VEGFA rs2010963 G/C, and VEGFA rs3025039 C/T polymorphisms were not associated with a risk of CAD.ConclusionsThese findings suggest that the functional MSRA rs10903323 G/A polymorphism is associated with CAD development. However, our results allow only a preliminary conclusion, which must be validated with a larger study of a more diverse ethnic population. |
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