| cGAS-STING信号通路与代谢性疾病的研究进展 |
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| 引用本文： | 王易,黄炜,徐勇.cGAS-STING信号通路与代谢性疾病的研究进展[J].医学分子生物学杂志,2021,18(1):68-72. |
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| 作者姓名： | 王易 黄炜 徐勇 |
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| 作者单位： | 西南医科大学临床医学院 四川省泸州市, 646000;西南医科大学附属医院内分泌代谢科 四川省泸州市, 646000;泸州市心血管代谢疾病重点实验室 四川省泸州市, 646000;四川省肾脏疾病临床医学研究中心 四川省泸州市, 646000 |
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| 基金项目： | 国家自然科学基金(No.81970676,81800741)。 |
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| 摘 要： | cGAS-STING信号通路是检测细胞内DNA的主要途径之一,病毒、 细菌和自体DNA都可通过cGAS-STING信号通路激活免疫系统.其中自体DNA通过cGAS-STING信号通路与非酒精性脂肪肝、脂肪组织炎症、胰岛素抵抗、糖代谢异常等代谢性疾病的发生相关.文章结合近年cGAS-STING信号通路与代谢性疾病的相关研...
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| 关 键 词： | cGAS-STING信号通路 自体DNA识别 代谢性疾病 |
Research Progress of cGAS-STING Signaling Pathway and Metabolic Diseases |
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| WANG Yi,HUANG Wei,XU Yong.Research Progress of cGAS-STING Signaling Pathway and Metabolic Diseases[J].Journal of Medical Molecular Biology,2021,18(1):68-72. |
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| Authors: | WANG Yi HUANG Wei XU Yong |
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| Institution: | (Clinical Medicine,Southwest Medical University,Luzhou,Sichuan,646000,China;Department of Endocrinology,Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan,646000,China;Luzhou Key Laboratory of Cardiovascular Metabolic Diseases,Luzhou,Sichuan,646000,China;Sichuan Clinical Research Center for Nephropathy,Luzhou,Sichuan,646000,China) |
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| Abstract: | The cGAS-STING signaling pathway is one of the main ways to detect DNA in cells.Virus,bacterial DNA and self-DNA can all activate the immune system through thecGASSTING signaling pathway.Among them,self-DNA is related to the occurrence of metabolic diseases such as non-alcoholic fatty liver,adipose tissue nflammation,insulin resistance,and abnormal glucose metabolism through the GAS-STING signaling pathway.This article combines recent studies on the cGAS-STING signaling pathway and metabolic diseases,summarizes the role of the cGASSTING signaling pathway in inflammation and the immune system,as well as the relationship etween its activation or loss and the occurrence of metabolic diseases,and unfolds the prospects of research on this signaling pathway and its treatment potential for related metabolic diseases. |
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| Keywords: | cGAS-STING signaling pathway self-DNA recognition nieta-holic diseases |
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