The antimicrobial activity of alpha-bisabolol and tea tree oil against Solobacterium moorei,a Gram-positive bacterium associated with halitosis |
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| Authors: | Marcel Forrer Eva M Kulik Andreas Filippi Tuomas Waltimo |
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| Institution: | 1. Institute of Preventive Dentistry and Oral Microbiology, School of Dental Medicine, University of Basel, Basel, Switzerland;2. Department of Oral Surgery, Oral Radiology and Oral Medicine and the Center of Dental Traumatology, School of Dental Medicine, University of Basel, Basel, Switzerland;1. Department of Pediatric Dentistry, College of Dental Medicine, United States;2. College of Pharmacy, United States;3. Department of Microbiology, College of Medical Sciences, United States;4. Department of Biochemistry, College of Medical Sciences and College of Allopathic Medicine, Nova Southeastern University, Ft. Lauderdale, FL-33328, United States;1. Laboratory of Microbiological Research, Centro Universitário Franciscano, Santa Maria, Brazil;2. Laboratory of Nanotechnology, Post Graduate Program of Nanosciences, Centro Universitário Franciscano, Santa Maria, Brazil;3. Laboratory of Phytochemical, Industrial Pharmacy Department, Universidade Federal de Santa Maria, Santa Maria, Brazil;4. Universidade Federal do Pampa, Bagé, Brazil;5. Laboratory of Chemical Solid State, Chemical Institute, Universidade Estadual de Campinas, Campinas, Brazil;6. Laboratory of Pharmacotechnique, Universidade Regional Integrada, URI-Santiago, Santiago, Brazil;7. Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Santa Maria, Brazil;1. Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 28789 East Jingshi Road, Jinan, 250103, Shandong Province, PR China;2. Key Laboratory for Drug Screening Technology of Shandong Academy of Sciences, 28789 East Jingshi Road, Jinan, 250103, Shandong Province, PR China;3. Yinfeng Cryomedicine Technology Co., Ltd, 1109 Gang Xin San Road, Jinan, 250103, Shandong Province, PR China;4. CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, 189 Songling Road, Laoshan District, Qingdao, 266101, Shandong Province, PR China;5. Department of Bioscience Technology, Chung Yuan Christian University, Chung-Li, Taiwan |
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| Abstract: | ObjectiveTo investigate the antimicrobial effect of alpha-bisabolol and tea tree oil alone and in combination against the halitosis-associated Gram-positive bacillus Solobacterium moorei.DesignThe inhibitory activity of alpha-bisabolol and tea tree oil against the reference strain S. moorei CCUG39336 and four clinical S. moorei isolates was investigated by a direct exposure test. Additionally, the ability of alpha-bisabolol to increase the sensitivity of S. moorei was tested by pretreating the bacteria with sublethal concentrations prior to the administration of tea tree oil.ResultsA dose-dependent killing was observed for the antimicrobial agents in a direct exposure test with the reference strain S. moorei CCUG39336. Concentrations of ≥0.5% tea tree oil caused decreases in viability of >5 log colony forming units/ml even after short incubation periods, while bacterial viability was less affected by alpha-bisabolol. The combination of 0.1% alpha-bisabolol plus 0.05% tea tree oil showed a synergistic effect on S. moorei strain CCUG39336 and on two of the four clinical S. moorei isolates tested. However, incubation of S. moorei with a sublethal concentration of 0.1% alpha-bisabolol for three days prior to the administration of 0.05% tea tree oil did not enhance the antibacterial effect of tea tree oil.ConclusionHalitosis-associated bacterium S. moorei is susceptible to the antimicrobial agents tea tree oil and alpha-bisabolol, suggesting that these compounds might be beneficial in oral healthcare products. |
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