Registro nacional de melanoma cutáneo. Características del tumor en el momento del diagnóstico: 15 años de experiencia |
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Authors: | L Ríos E Nagore JL López P Redondo RM Martí R Fernández-de-Misa B Soler |
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Institution: | 1. Servicio de Dermatología, Hospital Ramón y Cajal, Madrid, España;2. Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España;3. Servicio de Dermatología, Fundación Hospital de Alcorcón, Madrid, España;4. Servicio de Dermatología, Clínica Universitaria de Navarra, Pamplona, España;5. Servicio de Dermatología, Hospital Arnau de Vilanova-IRB Lleida, Lleida, España;6. Servicio de Dermatología, Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, España;7. Departamento Médico, E-C-BIO S.L. Madrid, España |
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Abstract: | Background and objectivesThe Spanish National Cutaneous Melanoma Registry (Registro Nacional de Melanoma Cutáneo RNMC]) was created in 1997 to record the characteristics of melanoma at diagnosis. In this article, we describe the characteristics of these tumors at diagnosis.Patients and methodsThis was a cross-sectional observational study of prevalent and incident cases of melanoma for which initial biopsy results were available in the population-based RNMC.ResultsThe RNMC contains information on 14,039 patients. We analyzed the characteristics of 13,628 melanomas diagnosed between 1997 and 2011. In total, 56.5% of the patients studied were women and 43.5% were men. The mean age of the group was 57 years (95% CI, 56.4-57 years) while median age was 58 years. The most common tumor site was the trunk (37.1%), followed by the lower limbs (27.3%). The most frequent clinical-pathologic subtype was superficial spreading melanoma (n = 7481, 62.6%), followed by nodular melanoma (n = 2014, 16.8%). Localized disease was observed in 86.2% of cases (n = 10,382), regional metastasis in 9.9% (n = 1188), and distant metastasis in 3.9% (n = 479). Independently of age at diagnosis, men had thicker tumors, more ulceration, higher lactate dehydrogenase levels, and a higher rate of metastasis than women (P < .001).ConclusionsBased on our findings, melanoma prevention campaigns should primarily target men over 50 years old because they tend to develop thicker tumors and therefore have a worse prognosis. |
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Keywords: | Melanoma Epidemiology Cancer Spain |
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