112例甲泼尼龙琥珀酸钠致过敏性报告分析

目的探讨甲泼尼龙琥珀酸钠致过敏反应的发生特点与规律,为临床安全、合理用药提供依据和参考。方法通过回顾性研究,2013年1月1日至2019年10月31日该市收集的112例甲泼尼龙琥珀酸钠致过敏反应报告进行整理分析。结果112例患者中男女比例为1.6∶1,0~3岁的占66.07%;原患疾病以呼吸系统为主,占67.87%;过敏反应以皮肤及其附件损害最多见(74.63%);96.43%的不良反应发生在用药当天,71.43%发生在用药后30 min内;110例患者经对症处理后好转或痊愈。结论临床需重视甲泼尼龙琥珀酸钠引起的过敏反应,一旦出现,需立即停药,并根据病情做对症处理。

112 Cases of Hypersensitivity Induced by Methylprednisolone Sodium Succinate

Objective To investigate the characteristics and regularity of hypersensitivity caused by methylprednisolone sodium succinate in order to provide reference for rational clinical use of drugs.Methods The data on 112 cases of ADRs induced by methylprednisolone sodium succinate that was collected by Weifang Center for ADR Monitoring between January 2013 and October 2019 was analyzed.Results Among the 112 patients,the ratio of males to females was 1.6:1,and 66.07%of them were 0-3 years old.The preexisting diseases mostly involved the respiratory system,accounting for 67.87%of the total.The most common manifestations of hypersensitivity were the damage to the skin and its accessories(74.63%).Meanwhile,96.43%of the ADRs occurred on the day of administration,and 71.43%within 30 minutes.In the end,110 patients were improved/cured after symptomatic treatment.Conclusion The hypersensitivity induced by methylprednisolone sodium succinate deserves more attention.Administration should be discontinued soon after ADRs occur and symptomatic treatment should start without delay.