The myeloperoxidase -463G/A polymorphism and coronary artery disease risk: A meta-analysis of 1938 cases and 1990 controls |
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| Authors: | Cuixian Chang Baorong Gao Zheng Liu Jianbin Mao Guoqiang Jiang |
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| Institution: | 1. Department of Cardiology, Sichuan Province Hospital of CAPF, Leshan, China;2. Department of Obstetrics and Gynecology, Molecular and Genetic Unit, Peking University People''s Hospital, Beijing, China;1. Dept. of Medical Sciences, Cardiology, Uppsala University, 75237 Uppsala, Sweden;2. Dept. of Medical Sciences, Clinical Chemistry, Uppsala University, 75237 Uppsala, Sweden;3. Uppsala Clinical Research Center, Uppsala University, 75237 Uppsala, Sweden;4. Dept. of Medicine, Division of Cardiology, University of Alberta, Edmonton, AB T6G2H7, Canada;5. Duke Translational Medicine Institute, Duke University School of Medicine, 2301 Erwin Road, Durham, NC 27710, USA;6. Thoraxcenter, Dept. of Cardiology, Erasmus Medical Center, ''s Grafendijkwal 230, 3000 CA Rotterdam, The Netherlands;1. Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada;2. Department of Clinical Pathology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada;1. Laboratory Department, Faculty of Medicine, University Hospital Center “Mother Teresa”, Tirana, Albania;2. Department of Laboratory Medicine AZ St Jan Av Brugge, UGent and KU, Leuven, Belgium;1. Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;2. Clinical Institute of Fuzhou General Hospital, Fujian Medical University, Fuzhou, China;3. Department of General Surgery, Fuzhou General Hospital, Nanjing Military Command, Fuzhou, China;4. Department of Newborn Medicine, Brigham and Women''s Hospital, Boston, MA, USA;1. Department of Laboratory Medicine, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium;2. Pôle de recherche en Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium;1. Department of Clinical Laboratory, Chinese People''s Liberation Army General Hospital, Beijing 100853, China;2. School of Laboratory Medicine and Life Science, Wenzhou Medical College, Whenzhou 325000, Zhejiang, China;3. Department of Hepatorenal, Beijing You''an Hospital, Capital Medical University, Beijing 100069, China;4. Beijing Strong Biotechnologies, Inc., Beijing 100233, China |
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| Abstract: | ObjectivesGenetic polymorphism of human myeloperoxidase (MPO) -463G/A has been implicated to alter the risk of coronary artery disease (CAD), but the results are controversial. To improve the reliability of the conflicting results, we conducted a meta-analysis of studies relating the MPO -463G/A polymorphism with the risk of CAD.Design and methodsTwo investigators independently searched the MEDLINE, EMBASE and Cochrane Library up to June, 2012. Summary odds ratios (OR) and 95% confidence interval (CI) for the MPO -463G/A polymorphism and CAD risk were calculated, and potential sources of heterogeneity and publication bias were explored. Statistical analysis was performed with the software program of Stata 9.0.Results5 case–control studies were finally identified for analyses, involving 1938 cases with CAD and 1990 controls. We found that the MPO -463G/A polymorphism has no significant association with overall CAD risk (G/G vs A/A: OR = 0.595, 95%CI = 0.298–1.188, P = 0.141; G/G vs G/A + A/A: OR = 0.886, 95%CI = 0.779–1.008, P = 0.066; G/G + G/A vs A/A: OR = 0.611, 95%CI = 0.334–1.119, P = 0.111; OR = 0.886, 95%CI = 0.779–1.008, P = 0.066; G vs A: OR = 0.843, 95%CI = 0.675–1.053, P = 0.133). The heterogeneity test showed that there were significant differences between individual studies in additive, recessive and allelic genetic models (P = 0.008, P = 0.021, P = 0.019, respectively); further analyses revealed that age and sex possibly account for the heterogeneity.ConclusionsOur meta-analysis demonstrated the evidence that there was no significant association between the MPO -463G/A polymorphism and the risk of CAD; larger and well-designed multicenter studies are needed to confirm our results. |
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