Heart transplantation for cardiac light chain amyloidosis with subsequent autologous stem cell transplantation |
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| Authors: | Tomas Honek Jan Krejci Lenka Spinarova Petr Hude Petr Nemec Zdenek Adam Alzbeta Sirotkova Vita Zampachova Jiri Vitovec |
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| Affiliation: | 1. International Clinical Research Center, Department of Cardiovascular Diseases, St. Anne''s University Hospital Brno and Masaryk University, Brno, Czech Republic;2. Center of Cardiovascular Surgery and Transplantation, International Clinical Research Center, St. Anne''s University Hospital Brno, Brno, Czech Republic;3. Department of Internal Medicine—Hematology and Oncology, University Hospital Brno and Masaryk University, Brno, Czech Republic;4. First Department of Pathological Anatomy, St. Anne''s University Hospital Brno, Brno, Czech Republic |
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| Abstract: | Our report describes a case of 57-year-old man with manifest heart failure on the basis of cardiac amyloidosis, which was detected by endomyocardial biopsy. Due to the heart failure, the patient was unable to undergo myeloablative therapy. We changed our previous decision for conservative therapy of heart failure and the patient underwent heart transplantation. Autologous stem cell transplantation was performed 6 months later. After the successful stem cell transplantation, the serum free light chain lambda levels promptly decreased. One year later, their levels started again to increase. Chemotherapy was therefore initiated. The patient has now completed the seventh cycle of chemotherapy in good condition. The graft function is normal and the latest endomyocardial biopsy revealed no amyloid. |
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| Keywords: | Heart failure Amyloidosis Heart transplantation Endomyocardial biopsy Autologous stem cell transplantation |
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