Associations between genetic polymorphisms of paraoxonase genes and coronary artery disease in a Taiwanese population |
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| Authors: | Chi-Ching Chen Chien-Chung Chen Jun-Da Tu Yi-Ling Wu Sy-Jye Leu |
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| Institution: | 1. Department of Pathology and Laboratory Medicine, Landseed Hospital, Taoyuan, Taiwan;2. Department of Cardiology, Landseed Hospital, Taoyuan, Taiwan;3. Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;4. Center for Reproductive Medicine and Sciences, Taipei Medical University, Taipei, Taiwan;1. Dept. of Medical Sciences, Cardiology, Uppsala University, 75237 Uppsala, Sweden;2. Dept. of Medical Sciences, Clinical Chemistry, Uppsala University, 75237 Uppsala, Sweden;3. Uppsala Clinical Research Center, Uppsala University, 75237 Uppsala, Sweden;4. Dept. of Medicine, Division of Cardiology, University of Alberta, Edmonton, AB T6G2H7, Canada;5. Duke Translational Medicine Institute, Duke University School of Medicine, 2301 Erwin Road, Durham, NC 27710, USA;6. Thoraxcenter, Dept. of Cardiology, Erasmus Medical Center, ''s Grafendijkwal 230, 3000 CA Rotterdam, The Netherlands;1. Laboratory Department, Faculty of Medicine, University Hospital Center “Mother Teresa”, Tirana, Albania;2. Department of Laboratory Medicine AZ St Jan Av Brugge, UGent and KU, Leuven, Belgium;1. Department of Laboratory Medicine, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium;2. Pôle de recherche en Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium;1. Cancer and Metabolism Research Laboratory, Saint-Joseph University, Faculty of Medicine, Beirut, Lebanon;2. Pulmonary and Critical Care Division, Hotel-Dieu de France Hospital, Saint-Joseph University, Faculty of Medicine, Beirut, Lebanon;3. Infectious Diseases, Infection Control and Employee Health, the University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA;1. Department of Clinical Laboratory, Chinese People''s Liberation Army General Hospital, Beijing 100853, China;2. School of Laboratory Medicine and Life Science, Wenzhou Medical College, Whenzhou 325000, Zhejiang, China;3. Department of Hepatorenal, Beijing You''an Hospital, Capital Medical University, Beijing 100069, China;4. Beijing Strong Biotechnologies, Inc., Beijing 100233, China |
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| Abstract: | ObjectiveWe evaluated the relationship between polymorphisms of the paraoxonase (PON) gene and the risk of coronary artery disease (CAD) in Taiwanese patients.MethodsOur sample set included 369 volunteers, classified into two groups: 162 healthy volunteers and 207 CAD patients aged 60.0 ± 9.7 and 64.3 ± 12.3 years, respectively. Polymorphisms of the PON1 and PON2 genes were determined using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) techniques.ResultsThe results indicate that for the PON1 gene, the homozygous genotype RR was found significantly more often among the CAD group compared with the healthy group (OR = 1.965, 95% CI = 1.223–3.159, p = 0.005). Furthermore, for the PON2 gene, the homozygous genotype CC was found significantly more often among the CAD group compared with the control group (OR = 2.525, 95% CI = 1.103–5.780, p = 0.026).ConclusionsIndividuals homozygous for the R allele of the PON1 gene and the C allele of the PON2 gene are more likely to have an increased risk of CAD. |
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