PAF-acether antagonistic pyrrolo[1,2-c]thiazoles: from RP 48740 to RP 59227 |
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| Authors: | D Lavé C James H Rajoharison A Floch C Robaut P Sedivy |
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| Affiliation: | Rh?ne-Poulenc Santé, Centre de Recherches de Vitry-Alfortville, Vitry-sur-Seine, France. |
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| Abstract: | The optimisation of the PAF antagonistic activity of RP 48740 led to the discovery of still more potent molecules of the pyrrolo[1,2-c]thiazole family: RP 52629, RP 52770 and RP 59227. The latter compound, for which a stereo-specific synthesis was developed, exhibits a very high potency as a PAF receptor antagonist. |
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