Interleukin 1 beta gene polymorphism and risk of cervical cancer. |
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Authors: | Ranbir Chander Sobti Dor Mohammad Kordi Tamandani Mohammad Shekari Pushpinder Kaur Keyanoosh Malekzadeh Vanita Suri |
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Affiliation: | Department of Biotechnology, Panjab University, Chandigarh, India. rcsobti@pu.ac.in |
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Abstract: | OBJECTIVE: To determine whether a polymorphism at position +3953 in exon 5 of the lL-1beta gene (IL-1beta +3953), a condition associated with an increased risk for a number of inflammatory diseases, is also involved in the development of cervical cancer. METHOD: We isolated DNA from peripheral blood in 150 women with cervical cancer and 200 healthy controls, and IL-1beta +3953 allele polymorphism was determined by polymerase chain reaction. RESULTS: Genotypes A1/A2 and A2/A2+A1/A2 were associated with increased risk of cervical cancer (odds ratio [OR], 2.88; 95% confidence interval [CI], 1.78-4.67; P<0.001 and OR, 2.85; 95% CI, 1.77-4.6; P<0.001, respectively). The risk in a passive smoker with A2/A2 or A1/A2 genotype was increased more than 5-fold (OR, 5.69; 95% CI, 2.61-12.50; P<0.001) compared with a nonsmoker with the A1/A1 genotype. CONCLUSION: This study provides evidence of an association between lL-1beta +3953 polymorphism and risk of cervical cancer. |
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Keywords: | Cervical cancer Interleukin 1 beta gene Polymorphism |
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