| 兔VX2肝癌改良模型的建立及螺旋CT评价 |
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| 引用本文： | 何东风,徐克,张曦彤,蒋宝国,邵海波,郭敏.兔VX2肝癌改良模型的建立及螺旋CT评价[J].中国医学影像技术,2005,21(12):1873-1876. |
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| 作者姓名： | 何东风 徐克 张曦彤 蒋宝国 邵海波 郭敏 |
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| 作者单位： | 1. 中国医科大学附属第一医院放射科,辽宁,沈阳,110001
2. 中国医科大学附属第四医院放射科,辽宁,沈阳,110001 |
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| 摘 要： | 目的探讨超声引导下经皮穿刺组织块注射法制作兔VX2肝癌模型,并与开腹组织块种植法进行比较.方法新西兰白兔24只,随机分成2组,12只/组,分别采用超声引导下经皮穿刺注射瘤组织块及开腹瘤组织块接种的方式种植于肝脏.肿瘤种植后14天,CT平扫及增强扫描与病理组织学结合评价肿瘤接种成功率及生长情况.结果肿瘤接种成功率两组均为91.7%.肿瘤最大直径穿刺组和开腹组分别为(1.04±0.12)cm和(1.09士0.14)cm,两种方法无统计学差异.肿瘤种植后发生感染率及肿瘤坏死率,开腹种植组(感染率:45.5%;坏死率:72.7%)明显高于经皮穿刺组(感染率:0;坏死率:27.3%),并有统计学意义(P＜0.05).结论超声引导下经皮穿刺注射瘤组织块建立兔VX2肝癌模型具有方法简单、成功率高、动物损伤小、肿瘤坏死率低等特点,为肝癌临床治疗和相关基础研究提供成熟的大型实验动物模型.
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| 关 键 词： | 肝 VX2肿瘤 动物模型 兔 体层摄影术 X线计算机 |
| 文章编号： | 1003-3289（2005）12-1873-04 |
| 收稿时间： | 2005-08-12 |
| 修稿时间： | 2005-11-03 |
The establishment of retrofit model of VX2 carcinoma in rabbit liver and spiral CT evaluation |
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| HE Dong-feng,XU Ke,ZHANG Xi-tong,JIANG Bao-guo,SHAO Hai-bo and GUO Min.The establishment of retrofit model of VX2 carcinoma in rabbit liver and spiral CT evaluation[J].Chinese Journal of Medical Imaging Technology,2005,21(12):1873-1876. |
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| Authors: | HE Dong-feng XU Ke ZHANG Xi-tong JIANG Bao-guo SHAO Hai-bo and GUO Min |
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| Institution: | Department of Radiology, the Fourth Affiliated Hospital of Chinese Medical University, Shenyang 110001, China;Department of Radiology, the First Affiliated Hospital of Chinese Medical University, Shenyang 110001, China;Department of Radiology, the First Affiliated Hospital of Chinese Medical University, Shenyang 110001, China;Department of Radiology, the First Affiliated Hospital of Chinese Medical University, Shenyang 110001, China;Department of Radiology, the Fourth Affiliated Hospital of Chinese Medical University, Shenyang 110001, China;Department of Radiology, the First Affiliated Hospital of Chinese Medical University, Shenyang 110001, China;Department of Radiology, the First Affiliated Hospital of Chinese Medical University, Shenyang 110001, China |
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| Abstract: | |
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| Keywords: | Liver VX2 carcinoma Animal model Rabbit Tomography X-ray computed |
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