盐酸氨溴索联合沙丁胺醇治疗慢性喘息性支气管炎急性发作

目的　评价盐酸氨溴索 (沐舒坦 )联合沙丁胺醇 (喘乐宁 )对慢性喘息性支气管炎急性发作的疗效。方法　 6 8例病人随机分组 ,测定基础肺功能。治疗组 36例给予沐舒坦注射液 30mg +NS 10mlivq12h ;治疗组与对照组 32例给予喘乐宁雾化溶液 5ml/ml+NS 10ml雾化吸入 2 0min ,每日 2次。于治疗后分别第 7天、第 14天评价临床治疗效果并检测肺功能参数 (FEV1、PEFR)。结果　治疗后第 7天、第 14天两组病人的咳嗽、咳痰及喘息症状明显好转 ,两组间治疗有效率比较差异有显著意义 (P <0 0 5 ) ;治疗组治疗后第 14天喘息症状与治疗后第 7天相比明显好转 ,组间比较差异有显著意义 (P <0 0 5 ) ;两组FEV1、PEFR的测定值与治疗前相比 ,差异有显著意义 (P <0 0 5 )。治疗后第 14天与治疗后第 7天FEV1、PEFR的测定值相比 ,治疗组的差异有显著意义 (P <0 0 5 ) ,而对照组的差异无显著意义 (P >0 0 5 )。结论　在慢性喘息性支气管炎急性发作期的临床常规治疗之外 ,适当延长沐舒坦用药时间 ,更加有利于病人临床症状的控制及肺功能的改善

The efficacy of mucosolvan and sulbutamol on the acute attack of chronic asthmatic bronchitis

Objective To evaluate the efficacy of mucosolvan and sulbutamol on the acute attack of chronic asthmatic bronchitis.Methods Sixty eight cases of patients with chronic asthmatic bronchitis were divided into treatment and comtrol groups in random.Nebulised sulbutamol 5mg/ml were sued in two groups,mucosolvan 30mg plus NS 10ml iv q12h were used only in control group.Clinical appraisal and pulmonary function(FEV 1,PEFR) were determined after 7 and 10 days.Results There were remarkable difference of the effective rates between treatment and control groups after 7 and 10 days(P<0.05).The difference of the effective rates of asthniatic syndrome were found between 7 and 10 days in control group(P<0.05).There were significant difference of the pulmonary parameters between 7 and 10 days in control group after treatment(P<0.05).Conclusion It is beneficial to control clinical symptoms and improve pulmonary function that duration of the treatment with mucosolvan prolongs appropriately in the acute attack of chronic asthmatic bronchitis.