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Increased expression level of corticotropin-releasing hormone in the amygdala and in the hypothalamus in rats exposed to chronic unpredictable mild stress |
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| Authors: | Shan-Shan Wang Xue-Bo Yan Michel A. Hofman Dick F. Swaab Jiang-Ning Zhou |
| Affiliation: | 1. Department of Neurology, Clinical Division of Nanlou, Chinese PLA General Hospital, Beijing, 100853, China 2. Hefei National Laboratory for Physical Sciences at Microscale and Department of Neurobiology and Biophysics, Life Science School, University of Science and Technology of China, Hefei, 230027, China 3. Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Science, Amsterdam, 1105BA, the Netherlands |
| Abstract: | ObjectiveCorticotropin-releasing hormone (CRH) plays an important role in neuroendocrine, autonomic and behavioral responses to stressors. In the present study, the effect of chronic unpredictable mild stress (CUMS) on CRH neurons was investigated in rat brain.MethodsThe rats were exposed to one of the stressors each day for 21 d. Immunostaining was performed to detect the CRH-positive neurons in the paraventricular nucleus (PVN) of the hypothalamus and in amygdala.ResultsAfter the stress protocol, the animals showed a reduction in body weight gain as well as reduced sucrose preference and locomotor activity. Interestingly, the CRH neurons in both PVN and central nucleus of the amygdala (CeA) were stimulated by CUMS. The densities of CRH-containing neurons in both PVN and CeA were significantly higher than those in control group.ConclusionThe CRH systems in PVN and CeA may both contribute to depression-like behaviors during CUMS. |
| Keywords: | chronic unpredictable mild stress hypothalamo-pituitary-adrenal axis corticotropin-releasing hormone amygdala paraventricular nucleus |
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