Slit2/Robo1 signaling in glioma migration and invasion |
| |
Authors: | Yun Xu Li Wen-Liang Fu Li Gu Feng Ma Yong-Jie |
| |
Institution: | 1. Central Laboratory of Oncology Department, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin, 300060, China 2. Department of Neurosurgery, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin, 300060, China 3. Department of Breast Pathology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin, 300060, China
|
| |
Abstract: | Slit2/Robo1 is a conserved ligand-receptor system, which greatly affects the distribution, migration, axon guidance and branching of neuron cells. Slit2 and its transmembrane receptor Robo1 have different distribution patterns in gliomas. The expression of Slit2 is at very low levels in pilocytic astrocytoma, fibrillary astrocytoma and glioblastoma, while Robo1 is highly expressed in different grades of gliomas at both mRNA and protein levels. Acquisition of insidious invasiveness by malignant glioma cells involves multiple genetic alterations in signaling pathways. Although the specific mechanisms of tumor-suppressive effect of Slit2/Robo1 have not been elucidated, it has been proved that Slit2/Robo1 signaling inhibits glioma cell migration and invasion by inactivation of Cdc42-GTP. With the research development on the molecular mechanisms of Slit2/Robo1 signaling in glioma invasion and migration, Slit2/Robo1 signaling may become a potential target for glioma prevention and treatment. |
| |
Keywords: | Slit2/Robo1 glioma invasion migration |
本文献已被 SpringerLink 等数据库收录! |
|