New developments in the epidemiology and genetics of gout |
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Authors: | Raihana Zaka and Charlene J Williams |
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Institution: | (1) Department of Medicine, Division of Rheumatology, Thomas Jefferson University, 233 South Tenth Street, 19107 Philadelphia, PA, USA |
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Abstract: | The prevalence of gout appears to be rapidly increasing worldwide and is no longer a disorder suffered primarily by over-fed
alcohol consumers. Emerging risk factors include longevity, metabolic syndrome, and new classes of pharmacologic agents. In
some ethnic populations, no obvious risk factors can explain the high incidence of hyperuricemia and gout, suggesting a genetic
liability. Studies to identify genes associated with gout have included families with defects in purine metabolism, as well
as families in whom the occurrence of gout is secondary to renal disorders such as juvenile hyperuricemic nephropathy and
medullary cystic kidney disease. Case-control studies of isolated aboriginal cohorts suffering from primary gout have revealed
several chromosomal loci that may harbor genes that are important to the development and/or progression of gout. |
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