| 泻心汤对糖尿病大鼠早期肾病的影响 |
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| 引用本文： | 吴家胜,陆雄,马越鸣,张宁.泻心汤对糖尿病大鼠早期肾病的影响[J].中草药,2010,41(1):73-77. |
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| 作者姓名： | 吴家胜 陆雄 马越鸣 张宁 |
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| 作者单位： | 1. 上海中医药大学中药药代动力学研究室,上海,201203
2. 上海中医药大学科技实验中心,上海,201203 |
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| 基金项目： | 国家自然科学基金资助项目(30873231); 上海市科委基金资助项目(09DZ1971700); 上海市教委基金资助项目(09ZZ129) |
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| 摘 要： | 目的研究泻心汤对高脂饮食联合注射链脲佐菌素(STZ)诱导的糖尿病大鼠早期肾病的影响。方法采用高脂饮食并注射低剂量链脲佐菌素方法复制糖尿病大鼠模型,随机分为模型组、泻心汤组及二甲双胍组,并设对照组;连续给药13周后,检测各组血糖(FBG)、糖化血红蛋白(HbAlc)、血脂(TG和TC)、血清胰岛素(INS)、肾功能、肾脏指数及尿蛋白,光镜、电镜下观察肾脏组织结构的变化。结果与模型组大鼠相比较,泻心汤给药13周明显缓解大鼠多食、多饮、多尿症状,降低HbAlc、胰岛素抵抗指数(IRI)、尿蛋白排泄率、肌酐清除率(CCr)和血脂水平,改善肾小球基底膜增厚及足突融合变化。结论泻心汤有抗实验性糖尿病大鼠早期肾病的作用,作用机制可能与其降低血脂和HbAlc及改善胰岛素抵抗等作用相关。
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| 关 键 词： | 泻心汤 糖尿病肾病 链脲佐菌素 |
| 收稿时间： | 5/5/2009 12:00:00 AM |
Effect of Xiexin Decoction on early diabetic nephropathy in diabetic rats |
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| WU Jia-sheng,LU Xiong,MA Yue-ming and ZHANG Ning.Effect of Xiexin Decoction on early diabetic nephropathy in diabetic rats[J].Chinese Traditional and Herbal Drugs,2010,41(1):73-77. |
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| Authors: | WU Jia-sheng LU Xiong MA Yue-ming and ZHANG Ning |
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| Institution: | WU Jia-sheng1,LU Xiong2,MA Yue-ming1,ZHANG Ning2(1.Laboratory of Pharmacokinetics,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China,2.Scientific Technology Experiment Center,China) |
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| Abstract: | Objective To investigate the effect of Xiexin Decoction(XXD) on the early diabetic nephropathy(DN) of diabetic rats induced by high-fat diet with injection of streptozotocin(STZ).MethodsMale Sprague-Dawley rats were divided into two groups and fed with normal pellet diet(NPD) or high-fat diet(HFD),respectively,for a period of four weeks and then HFD-fed rats were ip injected with STZ.The diabetic rats were divided into three groups: model group,XXD group,and metformin group.After 13-weeks ig administration,... |
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| Keywords: | Xiexin Decoction(XXD) diabetic nephropathy(DN) streptozotocin(STZ) |
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