| 丁酸对人牙周膜细胞增殖的影响 |
| |
| 引用本文： | 张旭,关颖,王进,安玉会. 丁酸对人牙周膜细胞增殖的影响[J]. 郑州大学学报(医学版), 2006, 41(5): 911-912 |
| |
| 作者姓名： | 张旭 关颖 王进 安玉会 |
| |
| 作者单位： | 郑州大学基础医学院生物化学教研室,郑州,450052;郑州铁路职工技术学院医学分院,郑州,450052 |
| |
| 摘 要： | 目的:探讨丁酸对人牙周膜细胞增殖的影响.方法:用含不同浓度丁酸(0 mol/L,2 mol/L,4 mol/L,8mol/L)的培养液培养人牙周膜细胞,通过MTT法测定其增殖.结果:人牙周膜细胞进入指数生长期后,丁酸以剂量依赖的方式抑制人牙周膜细胞的增殖.结论:丁酸可能通过抑制人牙周膜细胞的增殖,进而影响牙周膜的改建和更新,促进牙周袋形成和牙周组织破坏.
|
| 关 键 词： | 人牙周膜细胞 细胞增殖 丁酸 |
| 收稿时间： | 2005-12-05 |
| 修稿时间： | 2005-12-05 |
Effects of butyrate on the growth of cultured human periodontal ligament cells |
| |
| ZHANG Xu,GUAN Ying,WANG Jin,AN Yuhui. Effects of butyrate on the growth of cultured human periodontal ligament cells[J]. Journal of Zhengzhou University: Med Sci, 2006, 41(5): 911-912 |
| |
| Authors: | ZHANG Xu GUAN Ying WANG Jin AN Yuhui |
| |
| Affiliation: | 1 . Department of Biochemistry, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052; 2.College of Medical Sciences, Zhengzhou Railway Professional Technology College, Zhengzhou 450052 |
| |
| Abstract: | Aim: To explore the effect of butyrate on the growth of cultured human periodontal ligament cells (HPDLC).Methods:The growth velocity of cultured HPDLC in butyrate incubation solution with different concentrations(0 mol/L, 2 mol/L,4 mol/L, and 8 mol/L ) was determined by MTT.Results: Butyrate inhibited the growth of HPDLC in a dose-dependent manner.Conclusion: It is suggested that butyrate released by pathogenic microorganisms contributes to the gingival tissue dysfunction and breakdown through inhibiting the growth of HPDLC. |
| |
| Keywords: | human periodontal ligament cell cell proliferation butyrate |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
