Muscarinic agonist receptor subtypes in aging rat brain |
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Authors: | Roger S. Briggs Meryl M. Petersen Peter J. Cook |
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Affiliation: | 1. Department of Geriatric Medicine, Southampton General Hospital, Tremona Road, Southampton S09 4XY U.K.;2. Department of Medicine, Royal Free Hospital, Pond Street, Hampstead, London NW3 20G U.K. |
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Abstract: | Whole brain homogenates from rats aged 6 months (young) and 24 months (old) showed a decline with age of the pre-synaptic cholinergic marker, choline acetyltransferase, and also of total specific binding sites for the muscarinic antagonist L(?)quinuclidinyl benzilate (L-QNB). However, neither the proportion nor the inhibition constants of high and low affinity muscarinic agonist binding sites (defined by displacement of L-QNB binding with carbachol) changed with age. These findings may be relevant to the central cholinergic deficit reported to be associated with cognitive impairment in aging man. |
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Keywords: | Aging Muscarinic receptors Brain |
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