| 骨代谢标志物ICTP、BAP对肺癌骨转移的诊断意义 |
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| 引用本文： | Xin Y,Han B,Lou J,Wu J,Niu Y. 骨代谢标志物ICTP、BAP对肺癌骨转移的诊断意义[J]. 中国肺癌杂志, 2010, 13(10): 947-953. DOI: 10.3779/j.issn.1009-3419.2010.10.04 |
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| 作者姓名： | Xin Y Han B Lou J Wu J Niu Y |
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| 作者单位： | 1. 上海交通大学附属胸科医院肺内科,上海,200030
2. 上海交通大学附属胸科医院检验科,上海,200030 |
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| 摘 要： | 背景与目的骨代谢标志物是一类源于骨基质或骨细胞的代谢指标,可反映骨代谢情况。本研究旨在探讨血清骨代谢生化指标I型胶原交联羧基端肽(cross-linked telopeptide of type I collage,ICTP)和骨特异性碱性磷酸酶(bone-specific alkaline phosphatase,BAP)在肺癌骨转移诊断中的意义及其临床应用价值。方法采用前瞻性对照方法,共入组110例,分为3组。初治肺癌患者共90例,临床分期为IV期,分为骨转移组50例和非骨转移组40例,健康对照组20例,采用酶联免疫法和电化学发光免疫测定法检测所有入组者治疗前的血清骨代谢生化指标ICTP和BAP水平,对骨转移的各因素与血清ICTP和BAP的相关性进行统计学分析。结果骨转移组的血清ICTP和BAP水平显著高于非骨转移组和健康对照组(P<0.05)。多发性骨转移组(骨转移数≥3)的血清BAP水平显著高于少发性骨转移组(骨转移数<3)(P<0.05)。混合性骨转移组的血清BAP水平显著高于溶骨性骨转移组(P<0.05)。ICTP和BAP在肺癌骨转移诊断中的敏感性分别为18%和40%,特异性分别为98.3%和95...
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| 关 键 词： | 肺肿瘤 骨转移 ICTP BAP 酶联免疫法 电化学发光免疫分析法 |
Diagnostic value of bone metabolic markers ICTP and BAP in lung cancer patients with bone metastases |
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| Xin Yu,Han Baohui,Lou Jiatao,Wu Jing,Niu Yanjie. Diagnostic value of bone metabolic markers ICTP and BAP in lung cancer patients with bone metastases[J]. Chinese journal of lung cancer, 2010, 13(10): 947-953. DOI: 10.3779/j.issn.1009-3419.2010.10.04 |
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| Authors: | Xin Yu Han Baohui Lou Jiatao Wu Jing Niu Yanjie |
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| Affiliation: | Yu XIN1,Baohui HAN1,Jiatao LOU2,Jing WU2,Yanjie NIU1 1Department of Pulmonary Medicine,Shanghai Chest Hospital,Shanghai Jiaotong University,Shanghai 200030,China,2Department of Laboratory Medicine |
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| Abstract: | Background and objective Bone metabolic markers are biomarkers derived from bone matrix or osteocyte reflecting bone metabolic situation. The aim of this study is to explore the diagnostic value of bone markers, cross-linked telopeptide of type I collage (ICTP) and bone-specific alkaline phosphatase (BAP) in lung cancer patients with bone metastases (B.M). Methods As a prospective control study, 110 cases were enrolled and divided into 3 groups. Totally 90 pre-treated, stage IV lung cancer cases were divide... |
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| Keywords: | Lung neoplasms Bone metastases ICTP BAP Enzyme-linked immunoassay Electrochemilumines-cence immunoassay |
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