No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population |
| |
| Institution: | 1. Department of Exercise Science, Concordia University, Montréal, QC H4B 1R6, Canada;2. Department of Biology, Concordia University, Canada;3. PERFORM Centre, Concordia University, Canada;4. Center for Structural and Functional Genomics, Concordia University, Canada;5. Program in NeuroEngineering, McGill University, Montréal, QC H3A 2B4, Canada;6. Department of Neurology and Neurosurgery, Montréal Neurological Institute, McGill University, Canada;7. Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, Canada;1. Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Poland;2. Department of Molecular Pathology and Neuropathology; Medical University of Lodz, Poland;3. Department of Anaesthesiology and Intensive Cardiologic Care, 1st Chair of Cardiology and Cardiac Surgery, Medical University of Lodz, Poland;4. Department of Cardiac Surgery, 1st Chair of Cardiology and Cardiac Surgery, Medical University of Lodz, Poland;5. Department of Medical Psychology, Medical University of Lodz, Poland |
| |
| Abstract: | Several lines of evidence have suggested that the metabotropic glutamate receptor 3 (GRM3) gene is a candidate susceptibility gene for schizophrenia. To our knowledge, six studies have investigated the genetic association between GRM3 and schizophrenia, although the results have been quite controversial. In the present study, we investigated the association between the GRM3 gene and schizophrenia in 402 Japanese people by analyzing 10 single nucleotide polymorphisms (SNPs), including all SNPs that showed significant results in previous studies. We observed no significant difference in allelic frequencies or genotypic distributions of the 10 SNPs between the controls and patients. A permutation test showed no significant global differences in estimated haplotype frequencies between the controls and patients. Thus, the present study provides no positive evidence of an association between the GRM3 gene and schizophrenia in the Japanese population. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
