不同肠道疾病患者血清学指标与细胞因子的关系分析

：目的　分析不同肠道疾病患者的血清学指标与细胞因子的特点，进一步了解不同肠道疾病的发病情况。方法　收集 89 位肠道疾病患者的血清标本，进行血清细胞因子[白细胞介素（IL）-6、IL-9、IL-22]的免疫学检测，同时收集患者的临床数据。结果 89 例患者根据不同肠道疾病诊断分为肠道炎症组（35 例）、肠道肿瘤组（20 例）、肠道息肉组（17例）、肠道溃疡组（13 例）、肠梗阻组（4 例）。甲胎蛋白（AFP）在肠道炎症组显著高于其他 4 组（P<0.01），磷酸肌酸激酶（CK）、中性粒细胞（N）在肠道炎症组中的含量较高；乳酸脱氢酶（LDH）则在肠道溃疡组中的含量最高；肠梗阻组的嗜酸性粒细胞（E）含量低于肠道炎症组、肠道息肉组、肠道溃疡组（P<0.05）。IL-6、IL-9、IL-22 含量在肠道肿瘤组中最高，IL-6、IL-9含量在肠道溃疡组显著低于肠道炎症组和肠道肿瘤组（P<0.05）。相关分析结果显示，白细胞（WBC）、N、单核细胞（M）三者间存在中、高度相关关系（r=0.933、0.827、0.715，均P<0.01）；总胆红素（TBil）、直接胆红素（DBil）、间接胆红素（IBil）三者间也存在中、高度相关关系（r= 0.851、0.830、0.647，均P<0.01）。结论　肠道疾病中肠道炎症的占比最大，其次是肠道肿瘤； AFP、CK、N、LDH、E的含量在不同肠道疾病中存在差异，IL-6、IL-9 和IL-22 的含量在肠道肿瘤患者中最高，血清学指标WBC、N、M 三者之间或TBil、DBil、IBil三者之间中、高度相关，这对于肠道疾病的诊疗有重要意义。

Analysis on the relationship between serological indicators and cytokines in patients with different intestinal diseases

Abstract: Objective To explore the characteristics of serological indicators and cytokines in patients with different intestinal diseases and further understand the pathogenesis of different intestinal diseases. Methods Serum specimens were collected from 89 patients with intestinal diseases who sought medical treatment at the affiliated hospital of Medical College of Jiaying University from March 2021 to March 2022. Immunological testing was performed on serum cytokines (IL-6, IL-9, and IL-22), and clinical data of the patients were collected. Results 89 patients were divided into the Intestinal Inflammation Group (35 cases), the Intestinal Tumor Group (20 cases), the Intestinal Polyposis Group (17 cases), the Intestinal Ulcer Group (13 cases), and the Intestinal Obstruction Group (4 cases) based on the diagnosis of different intestinal diseases. The alpha fetoprotein (AFP) was significantly higher in the Intestinal Inflammation Group than that in the other five groups (P<0.01), and the contents of creatine phosphate kinase (CK) and neutrophils (N) was higher in the Intestinal Inflammation Group; The content of lactate dehydrogenase (LDH) was the highest in the Intestinal Ulcer Group; The content of eosinophils (E) in the Intestinal Obstruction Group was the lowest, and there was a significant difference when compared with the Intestinal Inflammation Group, Intestinal Polyposis Group, and Intestinal Polyposis Group (P<0.05). The contents of IL-6, IL-9, and IL-22 were the highest in the Intestinal Tumor Group, and the contents of IL-6 and IL-9 were significantly lower in the Intestinal Ulcer Group than those in the Intestinal Inflammation Group and Intestinal Tumor Group (P<0.05). The correlation analysis showed there was a medium to high correlation relationship among white blood cell (WBC), N, and monocyte (M) (r=0.933, 0.827, and 0.715, all P<0.01 for all); and there was also a medium to high correlation relationship among TBil, DBil, and IBil (r=0.851, 0.830, and 0.647, P<0.01 for all). Conclusion Among patients with different intestinal diseases, the proportion of intestinal inflammation is the highest, followed by intestinal tumors. There were significant differences in AFP, CK, N, LDH, and E in different intestinal diseases. The contents of IL-6, IL-9, and IL-22 were the highest in patients with intestinal tumors. There was a medium to high correlation among serum indicators such as WBC, N, and M and among TBil, DBil, and IBil, which is of great significance for predicting whether a patient has related intestinal diseases and evaluating the disease progression in the patient, as well as for early diagnosis and correct treatment of intestinal disease.