Chitosan and poly(methyl vinyl ether-co-maleic anhydride) microparticles as nasal sustained delivery systems |
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| Institution: | 1. Laboratory of Polymers, Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt;2. Nuclear Chemistry Department, Hot Laboratories Center, Atomic Energy Authority, Inshas, Cairo 13759, Egypt;2. Inorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, Greece;3. Department of Chemical and Process Engineering Technology, Jubail Industrial College, Jubail Industrial City, Saudi Arabia;1. Dental Biomaterials Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran;2. Marquette University School of Dentistry, Milwaukee, WI 53233, USA;3. Biomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran;4. Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, UK |
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| Abstract: | An original dosage form for nasal delivery based on the encapsulation of hydrophilic drug in chitosan-poly(methyl vinyl ether-co-maleic anhydride) (CH-PVM/MA) microparticles prepared by spray-drying technique was developed. Microparticles were characterized in terms of morphology, size, swelling properties, encapsulation efficiency and drug release. The physical state of the drug and the polymer was determined by scanning electron microscopy (SEM) and infrared spectroscopy (IR). Propranolol hydrochloride (PH) was a β-blocker, used for the treatment of hypertension and was chosen as a model of hydrophilic drug. SEM studies showed spherical particles with smooth surfaces for chitosan hydrochloride (CH-HCl), whereas rather gross surface defects resulted from the incorporation of poly(methyl vinyl ether-co-maleic anhydride) (PVM/MA). In vitro release studies revealed a sustained release of propranolol HCl from microparticles and in particular chitosan hydrochloride provided the lowest release of drug. |
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