Areas of intervention for genetic counselling of dementia: Cross-cultural comparison between Italians and Americans |
| |
| Institution: | 1. Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Utter Pradesh 226014, India;2. Clinical Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Utter Pradesh 226014, India;3. Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Utter Pradesh 226014, India;1. Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, USA;2. Department of Pediatrics, Columbia University Medical Center, New York, NY, USA;3. RTI, International D.C. Office, Washington, DC, USA;4. Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, Bethesda, MD, USA;5. Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA;6. Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA;7. Department of Medicine, Columbia University Medical Center, New York, NY, USA;8. Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;9. Broad Institute of MITCambridge, MA, USA;10. Department of Biomedical Data Science, Stanford University, Stanford, CA, USA;11. Department of Health Behavior, University of North Carolina, Chapel Hill, NC, USA;12. Department of Health Services, University of Washington, Seattle, WA, USA;13. John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ, USA;14. Georgetown University School of Medicine, Washington, DC, USA;15. Clinical Sequencing Exploratory Research Coordinating Center, University of Washington, Seattle, WA, USA;16. Department of Pharmacy, University of Washington, Seattle, WA, USA;17. Corrona, LLC, Waltham, MA, USA;18. Department of Population Science, City of Hope, Duarte, CA, USA;19. Department of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA, USA |
| |
| Abstract: | ObjectivePurposes of this study are: (1) to evaluate attitudes, beliefs and experiences towards dementia among relatives of Italian familial cases; (2) to perform a cross-cultural comparison between Italian and American samples; (3) to identify predictors of intentions to undergo hypothetical genetic testing.MethodsParticipants were 134 relatives of patients affected by familial forms of dementia. We administered tests measuring health psychological styles, social variables, illness perceptions, intentions regarding genetic testing, and perceptions of the pros and cons of genetic testing.ResultsRespondents had a poor Alzheimer's disease knowledge and a low perceived dementia threat. When compared to Americans, Italians reported greater willingness to undergo genetic testing and perceived a different subset of benefits and risks. The strongest predictors of test intention were decisional balance, homemaker status and two beliefs concerning dementia causes.ConclusionsItalians had a poor knowledge of the disease and a low awareness of personal risk of developing dementia. As compared to Americans, they expressed higher intentions to undergo genetic testing and they have a different perception of benefits and risks.Practice ImplicationsUnderstanding of cultural differences in knowledge, attitudes and perception of the disease is important to design optimal health services and education programs for dementia. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
