Abstract: | Objective To investigate the potential mechanism of galangal on depression based on network pharmacology
and molecular docking. Methods The active ingredients and targets of galangal, and target genes of depression were searched
from TCMSP and GeneCards databases, respectively. Protein interactions and PPI network diagram were obtained and
constructed by STRING database and Cytoscape 3.9.1 software, respectively. The core targets of galangal for depression were
screened, and their potential pathways were analyzed using GO function and KEGG enrichment analyses. Results Thirteen
active ingredients and 169 potential targets including JUN, MAPK1, AKT1, RELA, ESR1, IL6, MAPK14, MAPK8, and
RXRA were screened for depression treatment. GO analysis revealed 654 biological processes, 85 cellular components and 147
molecular functions. KEGG analysis uncovered 171 signaling pathways. Molecular docking results showed a strong binding
ability between main core targets and ingredients. Conclusion Ggalangal may treat depression through multiple targets and
pathways. |