联合抗抑郁药治疗功能性消化不良的临床研究

目的：探讨功能性消化不良治疗新途径及适应证。方法：将90例伴有抑郁焦虑症状的功能性消不良病人随机分为：抗消化不良组；抗抑郁组；综合治疗组，分别给予单抗消化不良治疗；单抗抑郁治疗；合并两种方法治疗。疗程均为8周。结果：三组患者的上腹胀、早饱、上腹痛、暖气症状评分、Zung自评量表分和HAMD量表评分，均较治疗前下降，但综合治疗化不请症状控制总有效率为86．7％HAMD量表评分达常模有效率为86．7％，高于抗消化不良组的36．7％和10．0％，抗抑郁组的43．3％，和16．7％，差异均有显著性。结论：伴有抑郁焦虑症的功能性消化不良，在治疗时联合使用抗抑郁药，能明显提高临床疗效。

Antidepressants in the treatment of functional dyspepsia

Objective To evaluate the role of antidepressants in the treatment of functional dyspepsia (FD). Methods 90 cases of FD with anxious depressive manifestations were randomizely allocated into antidyspepsia group, antidepressant group and antidyspepsia and antidepressants combination group. All patients were treated for 8 weeks. Results FD scores(upper abdominal distention, satiety, abdominal pain, belching) with Zung depression scale and HAMD scale decreased after treatment in all three groups. Symptoms in combination group improved with a total efficacy rate of 86.7%, and HAMD efficacy rate 86.7%. Both were much higher than those in antidyspepsia group(36.7% and 10.0%, respectively, P <0.05), and antidepressants group(43.3% and 16.7%, respectively, P <0.05). Conclusion Antidepressants combined with antidyspeptic medicine is helpful in the treatment of FD patients with anxious depressive manifestations.