| 错配修复基因hMLH1在膀胱移行细胞癌中的表达及其意义 |
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| 引用本文： | 刘辉,窦中岭,贾招辉,史海军,任素娟. 错配修复基因hMLH1在膀胱移行细胞癌中的表达及其意义[J]. 中华实验外科杂志, 2010, 27(3). DOI: 10.3760/cma.j.issn.1001-9030.2010.03.009 |
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| 作者姓名： | 刘辉 窦中岭 贾招辉 史海军 任素娟 |
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| 作者单位： | 河南科技大学第一附属医院泌尿外科,洛阳,471003 |
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| 摘 要： | 目的 观察错配修复基因hMLH1在膀胱移行细胞癌中的表达,探讨hMLH1与膀胱移行细胞癌的关系.方法 通过免疫组织化学方法 测定hMLH1在80例膀胱移行细胞癌中及20例正常膀胱组织中的表达.结果 hMLH1在膀胱移行细胞癌中的低表达率(32.5%)明显高于在正常膀胱组织中的低表达率(0%),差异有统计学意义(P＜0.05),且hMLH1在膀胱移行细胞癌中的低表达与肿瘤的分期分级有关(P＜0.05).结论 hMLH1的低表达与膀胱移行细胞癌的发生有关,与肿瘤的高分期和高分级有关,hMLH1的低表达在浸润性及分化差的膀胱移行细胞癌多见.
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| 关 键 词： | 膀胱移行细胞癌 基因表达 免疫组织化学 |
hML1 expression in transitional cell carcinoma of bladder |
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| LIU Hui,DOU Zhong-ling,JIA Zhao-hui,SHI Hai-jun,REN Su-juan. hML1 expression in transitional cell carcinoma of bladder[J]. Chinese Journal of Experimental Surgery, 2010, 27(3). DOI: 10.3760/cma.j.issn.1001-9030.2010.03.009 |
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| Authors: | LIU Hui DOU Zhong-ling JIA Zhao-hui SHI Hai-jun REN Su-juan |
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| Abstract: | Objective To study the expressions and significance of DNA mismatch repair gene hMLH1 protein in transitional cell carcinoma of bladder.Methods Immunohistochemistry was used to detect the expressions of hMlH1 in 80 cases of transitional cell carcinoma of bladder.20 cases of normal bladder tissues.Results Reduced expression rate of hMLHl in transitional cell carcinoma of bladder was 32.5%,significantly higher than that in control group(0%)(P＜0.05).The low expression of hMLH1 in transitional cell carcinoma of bladder was also correlated to clinical grade and stage(P＜0.05).Condusion Reduced expression of hMLH1 may play an important role in carcinogenesis and developmem of transitional cell carcinoma of bladder. |
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| Keywords: | Transitional cell carcinoma of bladder Gene expression Immunohistochemistry |
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