家兔葡萄球菌性发热及其热限的探讨

采用加热杀死的白色葡萄球菌菌体作激活物,给家兔耳缘静脉注射,观察剂量-发热效应,血浆EP的活性以及血浆和脑脊液中cAMP含量变化。结果表明,在一定的范围内,随剂量递增,发热效应相应加强,但达到一定浓度,可出现热限;发热时,血浆可检出循环EP;血浆致热活性,脑脊液cAMP含量随发热效应增强而升高,出现热限时,则不再升高。作者推论:cAMP可能是葡萄球菌性发热的重要中枢介质;EP的产生释放受限和体温调节中枢内cAMP的产生受限可能是构成葡萄球菌性热限的重要因素。

Studies in staphylococcal fever and its hyperthermic ceiling

Staphylococcus albus (St albus) given intravenously to conscious rabbits produced a dose-dependent fever. When the St albus doses reached a certain limit, hyperthermic ceiling was approached. The pyrogenicity of plasma increased progressively along with the increase of St albus doses. When hyperthermic ceiling was approached, pyrogenicity of plasma stopped raising any further. Fever induced by St albus was associated with a dose related increase in the concentration of cAMP in csf as well as that in the plasma. The increase of cAMP in plasma and in csf was limited at the occurrence of upper limit of fever. It is concluded that cAMP may be an important central mediator in the fever induced by staphylococci, whilst the limitation of production and release of EP and the limitation of increase of cAMP in central nervous system may be two important factors in "staphylococcus hyperthermic ceiling".