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Extranodal follicular dendritic cell tumour of the nasopharynx |
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| Authors: | C. Beham-Schmid A. Beham R. Jakse L. Auböck G. Höfler |
| Affiliation: | (1) Institute of Pathology, University of Graz Medical School, Auenbruggerplatz 25, A-8036 Graz, Austria, Tel.: (+43) 316-380-4406; Fax: (+43) 316-384329, AT;(2) Department of ENT, Krankenhaus der Elisabethinen, Graz, Austria, AT |
| Abstract: | We report the first case of an extranodal follicular dendritic cell (FDC) tumour localized in the nasopharynx of a 44-year-old male patient. The tumour cells were characterized immunohistochemically by strong expression of CD21, HLA-DR and vimentin and focal expression of CD68 and cytokeratin. Electron microscopic examination revealed desmosomal cell junctions between adjacent cell processes. Molecular genetic analysis using polymerase chain reaction (PCR) showed germline configuration of immunoglobulin and T-cell receptor genes. Epstein-Barr virus (EBV) genomes were detectable by PCR. After complete surgical tumour removal and radiotherapy the patient is disease-free 20 months after the initial diagnosis. Received: 21 July 1997 / Accepted: 12 September 1997 |
| Keywords: | Follicular dendritic cell tumour Nasopharynx Immunohistochemistry Electron microscopy PCR |
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