| 凋亡基因在肿瘤耐药中的作用 |
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| 引用本文： | 刘建夏,钱海鑫,左剑玲.凋亡基因在肿瘤耐药中的作用[J].江苏医药,2000,26(1):27-29. |
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| 作者姓名： | 刘建夏 钱海鑫 左剑玲 |
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| 作者单位： | 215006,苏州医学院附属第一医院外科 |
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| 摘 要： | 目的 观察凋亡基因ＣＤ９５／ＣＤ９５Ｌ在肿瘤细胞耐药机制中的作用。方法 用ＤＯＸ和ＣＨ－１１作用于人多发性骨髓瘤细胞株ＲＰＭＩ８２２６和耐药株ＲＰＭＩ８２２６／ＤＯＸ４０，观察肿瘤细胞的凋亡基因的表达和死亡情况。结果 敏感株细胞ＣＤ９５的表达高于耐药株，耐药株细胞获得对ＤＯＸ耐药的同时，也获得对ＣＤ９５的耐受。结论 ＣＤ９５／ＣＤ９５Ｌ系统涉及肿瘤耐药性的产生。
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| 关 键 词： | 肿瘤 耐药性 凋亡基因 CD95 |
| 修稿时间： | 1999-03-02 |
The Role of Apoptosis gene in Drug-Resistant Cell Lines |
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| LIU Jianxia,QIAN Haixin,ZUO Jinanling.The Role of Apoptosis gene in Drug-Resistant Cell Lines[J].Jiangsu Medical Journal,2000,26(1):27-29. |
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| Authors: | LIU Jianxia QIAN Haixin ZUO Jinanling |
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| Abstract: | Objective To evaluate the effect of apoptosis gene CD95/CD95L in drug resistant cell lines. Methods RPMI8226 and RPMI8226/DOX40 cells were treated with Dox and CH 11.Expression of CD95/CD95L and apoptosis were observed after treatment. Results CH 11 induced apoptosis in RPMI8226.But it has not such effects in RPMI8226/DOX cells. Conclusion CD95/CD95L system is involved in the mechanism of drug resistance. |
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| Keywords: | CD95 Apoptosis MDR |
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