| Preliminary Studies on the Relationship betweenAutoantibodies to Heat Stress Proteins and Heat Injury of Pilots during Acute Heat Stress |
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| 引用本文： | 熊一力,邬堂春,袁野,张永幸,张国高. Preliminary Studies on the Relationship betweenAutoantibodies to Heat Stress Proteins and Heat Injury of Pilots during Acute Heat Stress[J]. 华中科技大学学报(医学英德文版), 1997, 17(2): 83-85. DOI: 10.1007/BF02888240 |
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| 作者姓名： | 熊一力 邬堂春 袁野 张永幸 张国高 |
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| 作者单位： | XIONG Yili; WU Tangchun;ZHANG Yongxing;Tanguay R M，Nicole L，YUAN Ye;ZHANG Guogao(Hankou Airplane Hospital (No. 457)，Wuhan 430012)(Institute of Occupational Medicine，Tongji Medical University，Wuban 430030)(Lalsoratory of Molecular and Developmental Gen |
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| 摘 要： | Organismsrangingfrombacteriatohu-mansrespondtoheatbyinducingthesyn-thesisofagroupofproteinsknownasheatshockorstressproteins(HSPs)andinhibit-ingthesynthesisofnormalproteins['J.Be-causethesynthesisofHSPsisinducednotonlybyheatbutalsoavarietyofotherstress(theadverseconditionsofphysiologi-calstress:ischemia,hyperthermia,lowpHetc.andenvironmentalstress:ethanol,aminoacidanalogs,heavymetals,freerad-icals,virusinfectionetc.)[l'2J.HSPsmayhavesuchimportantbiologicalfunctionsasraisingtheresistancetohe…
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| 收稿时间： | 1996-01-19 |
Preliminary studies on the relationship between autoantibodies to heat stress proteins and heat injury of pilots during acute heat stress |
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| Xiong Yili,Wu Tangchun,Zhang Yongxing,R. M. Tanguay,L. Nicole,Yuan Ye,Zhang Guogao. Preliminary studies on the relationship between autoantibodies to heat stress proteins and heat injury of pilots during acute heat stress[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 1997, 17(2): 83-85. DOI: 10.1007/BF02888240 |
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| Authors: | Xiong Yili Wu Tangchun Zhang Yongxing R. M. Tanguay L. Nicole Yuan Ye Zhang Guogao |
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| Affiliation: | (1) Hankou Airplane Hospital (No. 457), 430012 Wuhan;(2) Institute of Occupational Medicine, Tongji Medical University, 430030 Wuhan;(3) Laboratory of Molecular and Developmental Genetics, Laval University, Quebec, Canada |
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| Abstract: | Comparison in the heart rate, oral temperature and lymphocyte DNAdamage during heat stress was made in pilots with negative antibodies to heatstress proteins (HSPs) and those with positive antibodies in the man-made climate room with Western blot and comet assay. Our results showed that the increase in oral temperature, heart rate and lymphocyte DNA damage in pilots with the posi-tive antibodies to HSPs were higher than those in pilots with the negative antibod-ies during heat stress. These results indicated that the presence of autoantibodies in plasma of pilots might reflect heat damage and high sensitivity to heat. |
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| Keywords: | antibodies heat stress proteins pilot heat stress |
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