坦度螺酮固定剂量治疗社交焦虑症的临床评价

目的:评价坦度螺酮治疗社交焦虑症的疗效和安全性。方法:用坦度螺酮和帕罗西汀进行随机双盲对照观察66例患者。采用Liebowitz社交焦虑量表(LSAS)、副反应量表(TESS)、临床总体印象量表(CGI)评价患者疗效和不良反应,并定期检查患者肝、肾功能、心电图、脑电图、血生化(Glu、K、Na、Cl)等。结果:坦度螺酮对社交焦虑症疗效与帕罗西汀相当,两组患者疗效分别为78.1%,79.4%,(P>0.05)。坦度螺酮的不良反应明显少于帕罗西汀(P<0.01)。结论:坦度螺酮是一种疗效较好、安全性较高的治疗社交焦虑症的药物。

Clinical evaluation of fixed-dose tandospirone in treatment of social anxiety disorder

Objective：To evaluate efficacy and safety of tandospirone in treatment of social anxiety disorder. Methods：66 so-cial anxiety disorder patients were divided into tandospirone and paroxetine for a random double-blind study. The efficacy and side effects were evaluated with Liebowitzs Social Anxiety Scale （ LSAS） , treatment emergent symptom scale （ TESS） , and clinical global impression scale （ CGI）;and then renal function, liver function, electrocardiogram （ ECG） , electroencephalogram （ EEG） , biochemi-cal analysis （ Glu, K, Na, Cl） and the like were tested. Results：The clinical efficacy had no significant difference between tandospi-rone and paroxetine. The effective rates of two groups were separately 78. 1% and 79. 4% （P〉0. 05）. The side effects of tandospirone were less than those of paroxetine （P〈0. 01）. Conclusions： Tandospirone is an effective and highly safe drug in the treatment social anxiety disorder.