| 异氟烷预处理对脑缺血再灌注大脑保护作用的实验研究 |
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| 引用本文： | 来炳祺,苏伟,叶荣. 异氟烷预处理对脑缺血再灌注大脑保护作用的实验研究[J]. 陕西医学杂志, 2012, 41(8): 939-941 |
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| 作者姓名： | 来炳祺 苏伟 叶荣 |
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| 作者单位： | 陕西省肿瘤医院麻醉科,西安,710061 |
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| 摘 要： | 目的:探讨全身麻醉药异氟烷对大鼠脑缺血再灌注后脑损伤的保护作用。方法:随机将20只SD大鼠分为2组,每组10只。氯胺酮(1mg/kg)分别对两组动物施行基础麻醉。对照组进行假手术;吸入组应用异氟烷持续吸入维持麻醉后进行手术,大脑缺血再灌注后取脑组织标本。测定脑组织NF-κB的含量以及脑组织形态学观察。结果:异氟烷对实验动物维持麻醉,可以有效地降低脑组织中NF-κB的含量,并且组织损伤性变化明显减轻。结论:异氟烷对大鼠脑缺血再灌注脑组织损伤具有明显的保护作用。
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| 关 键 词： | 脑缺血/并发症 再灌注损伤 @异氟烷 动物,实验 大鼠 |
Protective Effects of Isoflurane on Cerebral Injury from Cerebral Ischemia-reperfusion in Rats |
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| Lai Bingqi , Su Wei , Ye Rong. Protective Effects of Isoflurane on Cerebral Injury from Cerebral Ischemia-reperfusion in Rats[J]. Shaanxi Medical Journal, 2012, 41(8): 939-941 |
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| Authors: | Lai Bingqi Su Wei Ye Rong |
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| Affiliation: | Lai Bingqi Su Wei Ye Rong Department of Anesthesiology,tumour hospital of Shannxi province(Xi’an 710061) |
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| Abstract: | Objective: To study the protective effects of isoflurane on cerebral injury from cerebral ischemia-reperfusion in rats.Methods: 20 rats were randomly divided into two groups with 10 rats each group.The two groups were performed basic anesthesia with ketamine(1mg/kg).Direct surgery for control group,while experimental group were inhalationally anesthetized with isoflurane to maintain anesthesia during surgery at the same time.In two groups after cerebral ischemia-reperfusion,cerebral tissues were sampled.Observed morphological changes of the lung tissues and determined NF-κB in cerebral tissue.Results: Isoflurane anesthesia during cerebral ischemia-reperfusion in rats was effective in reducing NF-κB in cerebral tissue,and cerebral tissue damage became attenuated.Conclusion: Isoflurane was effective to cerebral injury from cerebral ischemia-reperfusion in rats. |
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| Keywords: | Brain ischemia/complications Reperfusion injury @Isoflurane Animals laboratory Rats |
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