TAT介导的几种纳米药物载体的研究概况

TAT是一种应用最早且现今最为常用的细胞穿膜肽,已经成功与多种纳米载体如脂质体、胶束、纳米粒等连结形成可内化进入细胞内的载药体系。文章主要对TAT介导的几种纳米载药体系的穿透机制、体内外抗肿瘤活性及靶向病变部位能力等方面的研究进行综述,同时对微环境pH敏感的TAT靶向药物载体的研究进展作了简单介绍。

The Development of TAT-Mediated Nanocarriers as Vectors for Drug Delivery

TAT as an earliest and most common Cell-penetrating peptide has been successfully used for intracellular delivery of a broad variety of cargoes including various nanoparticulate pharmaceutical carriers such as liposomes,micelles,nanoparticles etc.In this paper,the main results in TAT-mediated several nano-loading systems will be considered,with a special emphasis on the mechanism of penetrating the cell membrane barrier,the activity of antitumor in vitro and in vivo,the ability targeting lesion,and so on.At the same time the development of pH-sensitive nanocarriers,in which cell-penetrating function can be activated by the changing of the pH will be discussed.