1-6-二磷酸果糖对重度缺氧缺血性脑病新生儿神经行为能力的影响

目的:探讨1-6-二磷酸果糖(FDP)对重度新生儿缺氧缺血性脑病(HIE)患儿神经行为能力的影响。方法:符合入选条件的HIE患儿在常规治疗的基础上于入院后加用FDP250mg/kg,2次/d,静脉滴注,滴注时间<30min,连用10天,其前后各行1次NBNA测定;对照组为上1年住院的同一诊断标准下的重度HIE患儿,与观察组一样接受了除FDP以外的常规治疗和NBNA测定并有详细的评分记录。结果:观察组于FDP治疗后的NBNA评分明显优于对照组。其差异主要表现在行为能力和一般状态二方面。结论:在常规治疗的基础上加用FDP较单纯常规治疗有利于改善重度HIE患儿的神经行为能力,从而有助于改善预后。

Influences of fructose-1, 6-diphosphate on nervous behavior in newborn with severe hypoxic-ischemic encephalopathy

Objective:To study the influences of fructose-1,6-diphosphate (FDP) on nervous behavior in newborn with severe hypoxic-ischemic encephalopathy (HIE).Methods:In FDP group , FDP 250 mg/kg, twice a day, was injected by intravenous drip within 30 minutes after hospitalization lasting for 10 days besides routine therapy. NBNA was performed before and after therapy. The control group was severe HIE hospitalized last year who received routine therapy as well as NBNA except for FDP and had records in detail.Results:The NBNA score in FDP group was higher than that in control group. The difference was showed in behavior ability and general state.Conclusion:FDP plus routine therapy can obviously improve the nervous behavior and prognosis in newborn with severe HIE.