吸烟对短暂性脑缺血发作和脑梗死患者血清可溶性细胞间粘附分子1水平的影响

目的研究吸烟健康人群、短暂性脑缺血发作和脑梗死患者血清可溶性细胞间粘附分子1水平的变化,探讨吸烟在脑梗死发生发展中的作用。方法采用双抗体夹心法测定31例脑梗死吸烟者和31例脑梗死不吸烟者、31例短暂性脑缺血发作吸烟者和25例短暂性脑缺血发作不吸烟者以及26例健康吸烟者和28例健康不吸烟者血清可溶性细胞间粘附分子1水平;应用经颅超声多普勒仪测定脑血流速度和吸烟后10min脑血流速度。结果脑梗死吸烟组、短暂性脑缺血发作吸烟组和健康吸烟人群血清可溶性细胞间粘附分子1水平分别高于脑梗死不吸烟组、短暂性脑缺血发作不吸烟组和健康不吸烟人群(P<0.05),血清可溶性细胞间粘附分子1水平升高与吸烟指数呈正相关(r=0.428,P<0.01);吸烟10min后双侧大脑中动脉血流速度较吸烟前明显加快(P<0.05)。结论吸烟使健康人、短暂性脑缺血发作和脑梗死患者血清可溶性细胞间粘附分子1水平升高。可溶性细胞间粘附分子1参与了脑梗死的发生发展过程。

The Effect of Cigarette Smoking on the Soluble Intercellular Adhesion Molecule Level of Transient Ischemic Attack and Infarction Paitents

Aim To investigate the changes of serum soluble intercellular adhesion molecule-1 (sICAM-1) concentration among healthy smokers, transient ischemic attack (TIA) and cerebral infarct patients and to study the effects of smoking on the occurrence and development of cerebral infarct. Methods The level of serum sICAM-1 was measured by two-layer antibody sandwich enzyme-linked immunosorbent assay (ELISA) in 31 cases of smokers with cerebral infarct and 31 cases of non-smokers with cerebral infarct, 31 cases of smokers with TIA and 25 cases of non-smokers with TIA, 26 healthy smokers and 28 healthy non-smokers. The cerebral blood flow velocities were measured by transcranial doppler (TCD). Results The level of serum sICAM-1 in cases of smokers with cerebral infarct, TIA and healthy smokers were higher than that of non-smokers with cerebral infarct, TIA and healthy non-smokers respectively (P<0.05). The level of serum sICAM-1 was well correlated with smoking index (r=0.428,P<0.01). The blood flow velocity in bilateral MCA increased compared to that before smoking cigarette (P<0.05). Conclusion Smoking evaluates the sICAM-1 level of the health, transient ischemic attack and infarction patients. sICAM-1 is involved in the process of the occurrence and development of cerebral infarct.