| 细胞凋亡与肿瘤化疗的研究进展 |
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| 引用本文： | 张巍,顾岩.细胞凋亡与肿瘤化疗的研究进展[J].医学综述,2013,19(3):451-453. |
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| 作者姓名： | 张巍 顾岩 |
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| 作者单位： | 通辽市科尔沁区第一人民医院呼吸内科;内蒙古医学院附属医院呼吸内科 |
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| 摘 要： | 化疗中的耐药性是导致肿瘤治疗失败的主要原因,细胞凋亡通路的异常改变是导致肿瘤化疗耐药的重要原因。现通过总结研究凋亡基因与肿瘤化疗的文献,分析凋亡基因,如Caspase、p53、Bax、Fas/FasLX系统、c-myc、Ras等与肿瘤化疗的关系,以及抗凋亡基因,如Bcl-x、bcr/abl、sur-vivin等与肿瘤化疗的关系,为进一步探讨细胞凋亡与肿瘤化疗的关系提供参考。
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| 关 键 词： | 细胞凋亡 化疗 Caspase p53 Bax Bcl-x bcr/abl 生存素 |
Research Progress of Apoptosis and Chemotherapy for Cancer |
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| ZHANG Wei,GU Yan.Research Progress of Apoptosis and Chemotherapy for Cancer[J].Medical Recapitulate,2013,19(3):451-453. |
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| Authors: | ZHANG Wei GU Yan |
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| Institution: | 1.Department of Respiratory,the First People′s Hospital of Horqin District in Tongliao City,Tongliao 028000,China;2.Department of Respiratory,Affiliated Hospital of Inner Mongolia Medical University,010050 Huhhot,China) |
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| Abstract: | The drug resistance is the major cause of cancer chemotherapy failure,and the abnormal changes of cell apoptosis path is an important reason.Here is to make a review on the literature of the cell apoptosis gene and cancer chemotherapy to analyze the correlation between them,such as caspase,p53,Bax,Fas,FasLX system,and c-myc gene,Ras genes and so on,as well as anti-apoptotic genes such as Bcl-x,bcr/abl,survivin and so on,to provide a reference to further exploration of the relationship between apoptosis and cancer chemotherapy. |
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| Keywords: | Apoptosis Chemotherapy Caspase p53 Bax Bcl-x bcr/abl Survivin |
| 本文献已被 CNKI 等数据库收录！ |
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