纳米活性炭在小鼠体内的分布、存留及淋巴靶向性

目的：观察纳米活性炭在腹腔及机体各脏器中的分布。方法：取昆明种小鼠经一次腹腔或尾静脉注射纳米活性炭，多次不同时间点解剖小鼠，观察纳米活性炭的去向及在腹腔的存留情况。结果：经腹腔注射的纳米活性炭在腹腔内有明显的淋巴趋向性，腹腔内纳米活性炭有随时间减少的倾向，经静脉注射的纳米活性炭随血液可以分布到全身各个脏器。结论：纳米活性炭在体内有明显的淋巴靶向性，肾脏及肠管可能对纳米活性炭有排泄作用，机体有能力排泄纳米活性炭。

Observation of the lymph tissue-targeting property, retention in the abdomen and the distribution of the intraperitoneal activated carbon nano-particles in mice

Objective:To observe the distribution of the a ct ivated carbon nano-particles (ACN) in abdominal tissues and internal organs in mice. Methods: Mice were injected intravenously and intraperitoneally with the activated carbon nano-particles,and dissected at different time points after injection. Then th e distribution and retention of black carbon particles were observed macroscopic ally and microscopically. Results: The intraperitoneal ACN had obvious lymph-tissue-targeting property. The retention in the abdominal tissu es decreased as time went on after intraperitoneal injection. The intravenous AC N had wide distribution in the internal organs of the mice. Conclusion: Intraperitoneal ACN has lymph-tissue-targeting property and the intra venous ACN has wide distribution in internal organs of mice.