| 兔主动脉球囊损伤后TIMP～1的mRNA动态表达 |
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| 引用本文： | 陈海峰,浦晓东,林亚洲,吴志勇,林立芳. 兔主动脉球囊损伤后TIMP～1的mRNA动态表达[J]. 福建医药杂志, 2004, 26(2): 96-98 |
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| 作者姓名： | 陈海峰 浦晓东 林亚洲 吴志勇 林立芳 |
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| 作者单位： | 1. 福建医科大学省立临床学院心内科,350001
2. 福建省心血管病研究所心内科,350001 |
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| 摘 要： | 目的 探讨基质金属蛋白酶组织抑制因子-1(TIMP-1)mRNA在球囊损伤后的改变及可能作用。方法 在兔腹主动脉球囊损伤的模型上，应用RT—PCR的方法，观察TIMP-1 mRNA在球囊损伤后不同时间的表达情况。结果 TIMP-1 mRNA球囊损伤后第1天表达开始逐渐升高，第4天达高峰。结论 TIMP-1 mRNA球囊损伤后表达逐渐升高，第4天达高峰可能与再狭窄中、后期新生内膜形成及血管重塑有关。
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| 关 键 词： | 兔 主动脉球囊损伤 TIMP—1 mRNA 动态表达 球囊损伤 |
| 文章编号： | 1002-2600(2004)02-0096-03 |
Dynamic changes of TIMP-1 mRNA after balloon injure in aortic arteries of rabbits |
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| Chen Haifeng,Pu Xiaodong,Lin Yazhou,et al.. Dynamic changes of TIMP-1 mRNA after balloon injure in aortic arteries of rabbits[J]. Fujian Medical Journal, 2004, 26(2): 96-98 |
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| Authors: | Chen Haifeng Pu Xiaodong Lin Yazhou et al. |
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| Affiliation: | Chen Haifeng,Pu Xiaodong,Lin Yazhou,et al. Department of Cardiology,Shengli Medical College,Fujian Medical University,Fuzhou 350001,China |
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| Abstract: | Objective To investigate the alteration and function of TIMP-1 mRNA after balloon injure. Methods The time and spatial course of mRNA expression of TIMP-1 was examined on the model of balloon injure of rabbit aortic artery, with the method of RT-PCR. Results The expression of TIMP-1 mRNA began at the first day after balloon injure, reached the maximum at the fourth day. Conclusion The expression of TIMP-1 mRNA gradually strengthened and reached the maximum at the fourth day. It is concerned with the formation of neointima and vascular remodeling in the middle and late stage of restenosis. |
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| Keywords: | TIMP-1 Ballon injure Rabbit |
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