支原体肺炎患儿的血清淀粉样蛋白A及人软骨糖蛋白-39水平变化与及预后的相关性分析

目的 分析支原体肺炎(MP)小儿的血清淀粉样蛋白A(SAA)及人软骨糖蛋白-39(HC-gp39)水平及与病情的相关性,为科学预测MP患儿预后提供依据。方法 选取本院2015年2月-2017年2月收诊的110例支原体肺炎患儿纳入观察组,110例健康体检儿童纳入对照组。观察组患儿均予常规综合治疗。比较两组入院时及观察组治疗前后血清SSA、HC-gp39、IgA、IgG、IgM水平。观察组患儿根据治疗效果分为有效组与无效组,分析治疗前血清SSA及HC-gp39水平与预后的相关性。结果 观察组入院时的血清SSA、HC-gp39、IgG水平显著高于同期对照组(t=32.204,20.597,11.588,P＜0.05)。观察组治疗后的血清SSA、HC-gp39、IgG水平较治疗前显著降低(t=27.859,13.765,35.043,P＜0.05)。血清SSA、HC-gp39与IgG呈正相关(r=0.524,0.394,P＜0.05),与疗效呈负相关(r=-0.613,-0.502,P＜0.05)。结论 支原体肺炎患儿的血清SSA与HC-gp39水平明显高于健康儿童,且与IgG呈正相关,与病情严重比呈负相关。

Analysis of serum amyloid A and human cartilage glycoprotein-39 levels in children with mycoplasmal pneumonia and the correlation with prognosis

Objective To analyze levels of serum amyloid A(SAA)and human cartilage glycoprotein-39(HC-gp39) in children with mycoplasma pneumonia(MP),as well as the correlation with efficacy,in order to provide reference for predicting the prognosis of MP children. Methods Totally 110 MP children in Shiyan Maternal and Child Health Hospital were enrolled in the observation group and 110 healthy children were included in the control group from February 2015 to February 2017. The observation group was given conventional comprehensive treatment. The levels of serum SAA,HC-gp39,IgA,IgG and IgM of two groups at admission,before and after treatment in observation group were compared. After treatment,the observation group was divided into effective group and invalid group according to the treatment efficacy results. Pearson correlation analysis was used to determine the correlation between serum SSA and HC-gp39 levels before treatment and the efficacy. Results The serum SSA,HC-gp39,and IgG levels at admission in the observation group were significantly higher than those in control group(P<0.05). After treatment,the serum levels of SSA,HC-gp39,and IgG in observation group were lower than those before treatment(P<0.05). The serum SSA,HC-gp39 levels were positively correlated with IgG(r=0.524,0.394,P<0.05) and negatively related to efficacy(r=-0.613,-0.502,P<0.05). Conclusion The levels of serum SSA and HC-gp39 in MP children are significantly higher than those in healthy children,and are positively correlated with IgG and negatively correlated with efficacy.