调理剂M550的毒性研究（Ⅰ）

为了解调理剂Ｍ５５０的毒性，对其进行了系列的毒性试验。结果表明，大鼠急性经口、经皮的最大耐受剂量〉３．０ｇ／ｋｇ体重；家兔皮肤刺激试验；原液组和４％应用液组对皮肤无刺激作用；家兔眼粘膜刺激试验；原液且粘膜有明显的刺激作用，应用液组有轻度的刺激作用；

Studies on the Toxicity of Conditioner M550

In order to know the toxicity of a kind of conditioner called M550 in this paper,the systematic toxicity of M550 was studied according to the Procedure and Methods of Safety Evaluation for Cosmetics(GB-7919-87).The results showed.(1)the acute oral or dermal maximum tolerance dose(MTD)of M550 for rats was more than3.0 g(of effective ingredient)/Kg b.w;(2)the crude soltion of M550 and 4% solution(applied solution)of M550 could not cause dermal irritation in rabbits;(3)the crude M550 solution could cause obvious irritation while the 4% M550 solutionn caused slight irritation to rabbits' eye mucosas;(4)M550 could not cause any dermal allergy in cavia cobaya; and (5)the results of the mutagenicity Test: Ames Test, marrow micronucleus test and sperm deformity test in mice were all negative. Therefor,it is suggested by the above results that M550 had low toxicity but no mutagenicity, and could not cause irritation or allergy to skin at the concentration of 4% solution and that M550 is a good conditioner.