颅脑损伤患者血浆纤维蛋白原的测定及其意义

目的 探讨颅脑损伤患者血浆纤维蛋白原(FIB)对颅脑损伤的诊断和预后价值.方法 对92例颅脑损伤患者、40例正常人,采用Clauss凝固法分别测定血浆FIB.结果 血浆FIB下降程度与颅脑损伤严重程度相关,轻型组、中型组及重型组血浆FIB分别为(2.24±0.51)、(1.71±0.46)及(1.09±0.34)g/L,均低于正常对照组(P<0.01),其中重型组血浆FIB低于中型组(P<0.05),中型组血浆FIB又低于轻型组(P<0.05).结论 颅脑损伤患者血浆纤维蛋白原测定对颅脑损伤可能具有诊断和预后价值.

Clinical significance of plasnm fibrinogen levels in patients with craniocerebral injury

Objective To investigate the vale of plasma fibrinogen (FIB) determination for the diagnosis and prognosis of craniocerebra] injury.Methods FIB in the plasma was determined by the Clause method among the 92 patients with craniocerebral injury and 40 healthy controls.Results The re-duction of plasma FIB was related to the severity of the craniocerebral injury.The plasma FIB in the pa-tients with grade Ⅰ,grade Ⅱ and grade Ⅲ of craniocerebral injury was (2.24±0.51), (I.71±0.46) and (1.09±0.34) g/L,respectively,statistically lower than those in the controls (P <0.01).The plasma FIB level in the patients with grade Ⅲ was significantly lower than in those with grade Ⅱ (P<0.05), and that in the patients with grade Ⅱ was significantly lower than in those with grade Ⅰ (P<0.05).Conclu-sion Plasma FIB determination was of both diagnostic and prognostic value in the patients with traumatic brain injury.