深圳市甲型H1N1流感疫苗接种不良反应监测

目的对深圳市甲型H1N1流感疫苗接种不良反应的发生情况进行分析,为免疫策略的制定提供依据。方法从国家儿童预防接种信息管理系统中收集深圳市的疑似预防接种异常反应个案信息中的不良反应个案,使用SPSS17.0进行数据分析。结果 2009-10-31/2010-04-30,深圳市甲流疫苗接种累计报告不良反应210例,报告发生率为3.29/万,<3岁年龄组的不良反应发生率明显高于其他年龄组,而流动人口的不良反应发生率要明显低于其他职业。病例大多数为一般反应,多为24 h内出现症状,并以发热和过敏反应为主要表现。绝大多数病例预后良好。结论深圳市甲流疫苗接种后产生的不良反应以轻症为主,接种安全性较高。接种后发生的严重异常反应主要为严重的过敏反应,建议今后疫苗生产企业应对疫苗的成分进行更清楚的标识,以避免严重过敏反应的发生。经过一年的跟踪,接种甲流疫苗无神经系统的不良反应发生。

Surveillance of Adverse Events Following Influenza A(H1N1) Vaccination in Shenzhen

Objective To provide evidence for developing immunization strategies in Shenzhen by analyzing the surveillance data of adverse reaction following influenza A(H1N1) vaccination.Methods The information about adverse events in Shenzhen was collected from the Children’s Immunization Information System.The related date was collected from investigation tables of AEFI cases and the daily reports of influenza A(H1N1) vaccine from vaccination spots.SPSS 17.0 software was used for data analysis.Results The cumulative incidence rate of adverse reaction following Immunization of influenza A(H1N1) vaccination was 3.29 /104 in Shenzhen from October 31st,2009 to April 30th,2010.Among different age groups,the incidence rate of the group<3 years old was higher than other age groups,and the incidence rate in the floating population was lower than those of other occupations.Most symptoms of adverse events following vaccination were general reactions which mostly appeared within 24 hours.Fever and anaphylactic reaction was predominant.Most of these cases have good prognosis.Conclusions Most adverse events following vaccination in Shenzhent of adverse events were mild symptoms,with proved the high vaccination safety.The serious adverse reaction mainly was serious allergy reaction.It is suggested that vaccine capacity business should mark the composition of the vaccine more clearly to avoid the occurrence of serious allergy reaction.After one year’s track,no nervous system’s untoward effect following vaccination was discovered.